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DR Medhat MRCP

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Churg-Strauss syndrome<br />

- Is an ANCA associated small-medium vessel vasculitis.<br />

• Features<br />

Asthma<br />

Blood eosinophilia (e.g. > 10%)<br />

Paranasal sinusitis<br />

Mononeuropathy or polyneuropathy.<br />

Systemic vasculitis.<br />

p-ANCA positive in 60%.<br />

• Treatment :<br />

Steroids (high dose)<br />

Immunosuppressive drugs : cyclophosphamide or azathioprine.<br />

Leukotriene receptor antagonists (e.g Montelukast )may precipitate the disease<br />

Microscopic polyangiitis<br />

- It`s an ANCA associated small-medium sized vasculitis.<br />

- It shares with classic PAN in :<br />

o Necrotizing inflammation of the small-medium sized blood vessels<br />

o Microaneurysms & thrombosis.<br />

- It has its own criteria not found in classical PAN :<br />

o Pulmonary capillaritis is frequent.<br />

o Glomerulonephritis rather than just an arteritis of renal arterioels.<br />

- Treatment : same as classical PAN.<br />

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