DR Medhat MRCP

• TTT :
Elderly patients (the majority) : Conservative (e.g EPO & G-CSF)
< 60 years old with AML transformation : Intensive chemotherapy +
BM transplantation.
• Prognosis of MDS :
Very poor
Median survival is two years.
Patients are more likely to have serious infections or life-threatening bleeds than
blastic transformation
Pure red cell aplasia (PRCA):
- It`s selective absence of erythroid progenators in an otherwise normal bone marrow.
- It is diagnosed when there is unexplained anaemia and reticulocytopenia, with a
complete absence of red cell precursors in the bone marrow, but with preservation
of other cell lines.
• Assciation:
- Either spontaneously (Diamond-Blakfan syndrome) or associated with :
Thymoma.
Autoimmune.
Lymphoproliferative disorders.
Erythropoitin alpha TTT ( Abs against EPO react against red BM.)
• Treatment : is supportive with immunosuppression e.g with cyclosporin
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