DR Medhat MRCP

• Management
In primary care; a blood screen is usually sent to exclude reversible causes (e.g.
Hypothyroidism).
- NICE recommend the following tests:
1. FBC
2. U&E
3. LFTs
4. Calcium
5. Glucose
6. TFTs
7. Vitamin B12 and folate levels.
- Patients are now commonly referred on to old-age psychiatrists (sometimes
working in 'memory clinics').
سؤال هام In secondary care ; neuro-imaging (MRI) is performed
- To exclude other reversible conditions (e.g. Subdural haematoma, normal
pressure hydrocephalus) and help provide information on aetiology to guide
prognosis and management.
Alzheimer`s disease
• Def : - Alzheimer's disease is a progressive degenerative disease of the brain
Accounting for the majority of dementia seen in the UK (60%).
- It may be defined as a clinic-pathological entity where there are histological
changes in the form of of neuro-fibrillary tangles and senile plaques in a patient
with dementia.
Neurofibrillary tangles : are aggregates of hyperphosphorylated tau protein .
Senile plaques : are extracellular deposits of beta amyloid in the gray matter
of the brain
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