DR Medhat MRCP

Fatty liver (steatosis)
- It`s liver enlargement due to accumulation of fat (TG & other lipids)in the liver cells.
- It`s divided into :
1) Alcohol-related steatosis (discussed before).
2) Non-alcohol related steatosis (non-alcoholic fatty liver diseases): due to
o Obesity.
خد بالك I) o DM type II (Insulin resistance) (not type
o DLP
o Others : cushing, ,pregnancy, steroids,tetracycline,amiodarone.
- If associated with inflammatory cell infiltration ,then it`s called steatohepatitis which
is either :
1) Alcoholic steatohepatitis (discussed before) or
2) Non-alcoholic steatohepatitis (NASH).
- It can progress to fibrosis & cirrhosis.
Non-alcoholic fatty liver disease (NAFLD)
- It`s is now the most common cause of liver disease in the developed world.
- It is largely caused by obesity and describes a spectrum of disease ranging from:
Steatosis : fat in the liver
Steatohepatitis : fat with inflammation, non-alcoholic steatohepatitis (NASH)
Fibrosis and liver cirrhosis.
- NAFLD is thought to represent the hepatic manifestation of the metabolic syndrome
and hence insulin resistance is thought to be the key mechanism leading to steatosis.
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