DR Medhat MRCP

- Chemotherapy includes :
1. Doxorubicin
2. Bleomycin
3. Vincristine
4. Cyclophosphamide and other cytotoxic drugs.
Non-Hodgkin’s Lymphomas
- Are a diverse group of lymphomas that include any kind of lymphoma except
Hodgkin's lymphomas.
- Types of NHL vary significantly in their severity, from indolent to very aggressive.
- Low-grade lymphoma is predominantly a disease of older people.
- Most non-Hodgkin’s lymphomas are of B cell phenotype, though T cell tumours are
increasingly being recognized.
سؤال - Mycosis fungoides = Cutaneous T-cell lymphoma
• Presentation:
Non-Hodgkin's lymphoma (NHL) is typically disseminated at presentation.
Constitutional symptoms :
o Pyrexia
o Weight loss ( loss of > 10% of BW in 6 months).
o Night sweats (characteristic for NHL).
Lymphadenopathy :
o Often generalized (in contrast to Hodgkin`s lymphoma which tend to be
localized to certain group of LN.
o Painless, non-tender , asymmetrical & rubbery LN.
o Visceral lymphadenopathy is common
Extra-nodal presentation is more common than Hodgkin's disease.
o Skin : mycosis fungoids (cutaneous T-cell lymphoma).
o GIT : hepatosplenomegaly , Burkitt's lymphoma often presents with a large
abdominal mass and symptoms of bowel obstruction.
o Kidney : Renal impairment (usually due to obstructive hydronephrosis
o Lymphoblastic lymphoma : mediastinal mass , SVC compression, cr nerve
palsy.
o Testis : testicular mass.
Anaemia, leucocytosis and/or thrombocytopaenia are suggestive of bone marrow
infiltration.
56