DR Medhat MRCP

Diffuse proliferative glomerulonephritis
Causes :
1) Post infectious : classical post-streptococcal glomerulonephritis in child (4 weeks
post infection).
2) SLE : Most common form of renal disease in SLE (WHO class V).
Presentation :
Presents as nephritic syndrome / ARF.
Pathology :
LM : Proliferation & hypercellularity of glomerular capillary endothelium.
IF : extensive subepithelial immune deposits of IgG & C3.
Investigations :
Urine R/M : tea (Cola)-like urine , hematuria , proteinuria.
Abdominal U.S : normal kidneys
Low C3
May be impaired RFT
Management : according to underlying cause e.g
If post-infection : prognosis is excellent & complete recovery is achieved with
conservative TTT : e.g fluids , BP control , restriction of high K diet , daily urine R/M.
If lupus nephritis : pulse methyl prednisone followed by oral prednisolone +
immunsuppression (Cyclophosphamide , MMF).
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