Sokal index (Kliniske oplysninger fra debuttidspunkt) Thrombocyttal mia/L Miltstørrelse (cm under curvaturen) Procent blaster i perifert blod Alder Klik her <strong>for</strong> at <strong>for</strong>etage en automatisk beregning af Sokal index'et. Klik her <strong>for</strong> at <strong>for</strong>etage en automatisk beregning af Has<strong>for</strong>d score: (www.kompetenznetz-leukaemie.de/cgi-bin/pharmacoepi/cmlscore) Referencer vedrørende HCT af CML Prognostiske faktorer Has<strong>for</strong>d, J., Pfirrmann, M., Hehlmann, R., Allan, N.C., Baccarani, M., Kluin-Nelemans, J.C., Alimena, G., Steegmann, J.L., and Ansari, H. A new prognostic score <strong>for</strong> survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee <strong>for</strong> the Collaborative CML Prognostic Factors Project Group. J Natl Cancer Inst, 90: 850-858, 1998. Sokal, J.E., Cox, E.B., Baccarani, M., Tura, S., Gomez, G.A., Robertson, J.E., Tso, C.Y., Braun, T.J., Clarkson, B.D., and Cervantes, F. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood, 63: 789- 799, 1984. Sokal, J.E., Baccarani, M., Tura, S., Fiacchini, M., Cervantes, F., Rozman, C., Gomez, G.A., Galton, D.A., Canellos, G.P., and Braun, T.J. Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation. Blood, 66: 1352-1357, 1985. Wadhwa, J., Szydlo, R. M., Apperley, J. F., Chase, A., Bua, M., Marin, D., Olavarria, E., Kanfer, E., and Goldman, J. M. Factors affecting duration of survival after onset of blastic trans<strong>for</strong>mation of chronic myeloid leukemia. Blood, 99: 2304-2309, 2002. Behandlingsstrategi Baccarani,M., Cortes,J., Pane,F., Niederwieser,D., Saglio,G., Apperley,J., Cervantes,F., Deininger,M., Gratwohl,A., Guilhot,F., Hochhaus,A., Horowitz,M., Hughes,T., Kantarjian,H., Larson,R., Radich,J., Simonsson,B., Silver,R.T., Goldman,J., & Hehlmann,R. (2009) Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J.Clin.Oncol., 27, 6041-6051. Goldman,J.M. (2007) How I treat chronic myeloid leukemia in the imatinib era. Blood, 110, 2828-2837. Shah,N.P. (2007) Medical Management of CML. Hematology.Am.Soc.Hematol.Educ.Program., 2007, 371-375. Bran<strong>for</strong>d,S. (2007) Chronic myeloid leukemia: molecular monitoring in clinical practice. Hematology.Am.Soc.Hematol.Educ.Program., 2007, 376-383. Imatinib/STI-571 Druker,B.J., Guilhot,F., O'Brien,S.G., Gathmann,I., Kantarjian,H., Gattermann,N., Deininger,M.W., Silver,R.T., Goldman,J.M., Stone,R.M., Cervantes,F., Hochhaus,A., Powell,B.L., Gabrilove,J.L., Rousselot,P., Reiffers,J., Cornelissen,J.J., Hughes,T., Agis,H., Fischer,T., Verhoef,G., Shepherd,J., Saglio,G., Gratwohl,A., Nielsen,J.L., Radich,J.P., Simonsson,B., Taylor,K., Baccarani,M., So,C., Letvak,L., & Larson,R.A. (2006) Five-year follow-up of patients receiving imatinib <strong>for</strong> chronic myeloid leukemia. N.Engl.J.Med., 355, 2408-2417. 56
Mauro,M.J. (2006) Defining and managing imatinib resistance. Hematology.Am.Soc.Hematol.Educ.Program., 219-225. O'Hare,T., Eide,C.A., & Deininger,M.W. (2007) Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure <strong>for</strong> chronic myeloid leukemia. Blood, 110, 2242-2249. Marin, D., et al. "European LeukemiaNet criteria <strong>for</strong> failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor." Blood 112.12 (2008): 4437- 44. Interferonbehandling versus kemoterapi Interferon alfa versus chemotherapy <strong>for</strong> chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group. J Natl Cancer Inst, 89: 1616-1620, 1997. Gale, R.P., Hehlmann, R., Zhang, M.J., Has<strong>for</strong>d, J., Goldman, J.M., Heimpel, H., Hochhaus, A., Klein, J.P., Kolb, H.J., McGlave, P.B., Passweg, J.R., Rowlings, P.A., Sobocinski, K.A., and Horowitz, M.M. Survival with bone marrow transplantation versus hydroxyurea or interferon <strong>for</strong> chronic myelogenous leukemia. The German CML Study Group. Blood, 91: 1810-1819, 1998. Guilhot, F., Chastang, C., Michallet, M., Guerci, A., Harousseau, J.L., Maloisel, F., Bouabdallah, R., Guyotat, D., Cheron, N., Nicolini, F., Abgrall, J.F., and Tanzer, J. Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. N Engl J Med, 337 : 223-229, 1997. Interferonbehandling før HCT Morton, A.J., Gooley, T., Hansen, J.A., Appelbaum, F.R., Bruemmer, B., Bjerke, J.W., Clift, R., Martin, P.J., Petersdorf, E.W., Sanders, J.E., Storb, R., Sullivan, K.M., Woolfrey, A., and Anasetti, C. Association between pretransplant interferon-alpha and outcome after unrelated donor marrow transplantation <strong>for</strong> chronic myelogenous leukemia in chronic phase. Blood, 92: 394-401, 1998. Autolog HCT Bhatia, R., Verfaillie, C.M., Miller, J.S., and McGlave, P.B. Autologous transplantation therapy <strong>for</strong> chronic myelogenous leukemia. Blood, 89: 2623-2634, 1997. HCT med søskendedonor van Rhee, F., Szydlo, R.M., Hermans, J., Devergie, A., Frassoni, F., Arcese, W., de Witte, T., Kolb, H.J., Niederwiser, D., Jacobsen, N., Gahrton, G., Bandini, G., Carreras, E., Bacigalupo, A., Michallet, M., Ruutu, T., Reiffers, J., Goldman, J.M., Apperley, J., and Gratwohl, A. Long-term results after allogeneic bone marrow transplantation <strong>for</strong> chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group <strong>for</strong> Blood and Marrow Transplantation. Bone Marrow Transplant, 20: 553-560, 1997. Radich,J.P., Gooley,T., Bensinger,W., Chauncey,T., Clift,R., Flowers,M., Martin,P., Slattery,J., Sultan,D., & Appelbaum,F.R. (2003) HLA-matched related hematopoietic cell transplantation <strong>for</strong> chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen. Blood, 102, 31-35. HCT med MUD Davies, S. M., DeFor, T. E., McGlave, P. B., Miller, J. S., Verfaillie, C. M., Wagner, J. E., and Weisdorf, D. J. Equivalent outcomes in patients with chronic myelogenous leukemia after early transplantation of phenotypically matched bone marrow from related or unrelated donors. Am.J.Med., 110: 339-346, 2001. 57
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Rekommandationer for knoglemarvstra
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Vævstyper og terminologi Ved valg
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- Page 13 and 14: Akutte Leukæmier ALL hos voksne AL
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- Page 47 and 48: tiltagende. Patienter med RC og hø
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- Page 59 and 60: LYMFOMER Lymfoblastært lymfom Lymf
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- Page 75 and 76: Marginal Zone Lymfom Senest revider
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Introduktion Retransplantation af b
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Den samlede konklusion kunne være,
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Thalassæmier Senest revideret nove
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thalassæmifri overlevelse på 66%
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Kronisk granulomatøs sygdom Senest