Program including abstracts as pdf available here

P 41
Title
zOLEDRONIC ACID AND RADIATION: ACCELERATED TOXICITy
Authors
A. OLIVARES RuEDA 1 , M. ALCARAz 1 , D. ARMERO 2 , M. ALCARAz-SAuRA 1 , D. ACHEL 3 ,
J. CASTILLO 4
Affiliations
1 Department of Radiology and Physical Medicine , Faculty of Medicine/Dentistry. University of
Murcia, MURCIA, SPAIN, 2 Department of Nursing, Faculty of Medicine/Dentistry. University of
Murcia, MURCIA, SPAIN, 3 Applied Radiation Biology Centre, Radiological and Medical Sciences
Research Institute, Ghana Atomic Energy Commission, LEGON-ACCRA, GHANA, 4 Research and
Development Department of Nutrafur-Furfural Español S.A., MURCIA, SPAIN
Body
Objetive: To determine the radiosensitization capacity of Zoledronic acid (Z) in the combined
treatment with ionizing radiation (IR) by evaluating its genotoxic and cytotoxic capacity in
non-tumoral cells.
Methods: The genotoxic effect of Z was studied by means of the micronucleus test in cytokinesis-blocked
cells of human lymphocytes irradiated (CBMN) before and after of 2 Gy of X-rays,
while the cytotoxic effect was studied by a cell viability test (MTT) in the PNT2 (normal prostate)
cell line before and after exposure to different X-ray doses (0Gy-20Gy) in four groups (Z
alone, radiation alone, Z+IR and IR+Z).
Results: A dose-dependent and time-dependent cytotoxic effect of Z and IR on PNT2 cells in
vitro (p>0.001) was demonstrated. With the concentrations recommended for humans, the
combined treatment had a more pronounced effect than individual treatments (p