Program including abstracts as pdf available here
Program including abstracts as pdf available here
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OP 41<br />
Title<br />
CAPAbILITy OF ADIPOSE DERIVED STEM CELL bONE IN REPARING bONE DEFECT<br />
Authors<br />
N. KHALIGHINEJAD 1 , M. SHEIKHI 2 , N. POOREbRAHIM 3 , E. SADEGHI 4 , H. bADRIAN 1 ,<br />
H. GOROHI 1<br />
Affiliations<br />
1 Student of dentistry, ISFAHAN, IRAN, 2 Associate professor, Department of Oral Radiology,<br />
ISFAHAN, IRAN, 3 Assistant professor, Department of oral and maxillofacial surgery, ISFAHAN,<br />
IRAN, 4 DENTIST, ISFAHAN, IRAN, 5 1, ISFAHAN, IRAN, 6 1, ISFAHAN, IRAN<br />
Body<br />
Objectives: complete healing of bone defects is so important for further prosthetic treatments<br />
because of limitations of auto-genic grafts. Today, osteogenic cells driven from stem cells are<br />
prescribed. As precise and sensitive clinical method is necessary to evaluate the bone formation,<br />
this study w<strong>as</strong> designed to compare autogenic graft a stem cells in bone regeneration by<br />
digital Radiography.<br />
Methods: In this experimental animal study, 4 doges were used. Incisor teeth of dogs were<br />
extracted and two 15 mm bone defects were created in each quadrant of maxilla from crest<br />
to n<strong>as</strong>al floor and surgical stant w<strong>as</strong> placed and 2 month were allowed for healing of defects<br />
followed by repair with tissue engineered bone from adipose derived stem cells in one side and<br />
tibia auto graft in another side. Bone regeneration w<strong>as</strong> evaluated by digital radiography and<br />
digital densitometers after 15, 30, 45, 60, 75 and 90 days of graft surgery. Data were analyzed<br />
using ANOVA for repeated data α=0.05.<br />
Result: In all stages, the difference between two side w<strong>as</strong> not statistically significant regarding<br />
the density of formed bone P value=0.942. But almost in most of the follow up periods,<br />
the density of bone related to stem cells were more than auto-genic bone grafts. Bone formed<br />
by auto-grafts had homogenous appearance and cotton wool feature w<strong>as</strong> seen in stem cells<br />
method.<br />
Conclusion:Tissue engineered bone from adipose derived stem cell provide an acceptable alternative<br />
for c<strong>as</strong>es with limited source of auto graft.<br />
Keywords<br />
digital radiography, bone defect, Tissue engineering of bone<br />
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