LVR-Klinikum Düsseldorf Hospital of the Heinrich-Heine University ...

LVR-KLINIKUM DÜsseLDORF – hOsPITaL OF The heINRIch-heINe UNIVeRsITY DÜsseLDORF
3.1.3.6 Comorbidity in people with mental disorders
Director: J. Cordes
Scientific assistants: G. Regenbrecht,
C. Schmidt-Kraepelin, F. Hellen, K. Beseoglu, L. Kostorz
Doctoral candidates: P. Messinger, O. Messinger,
M. Woite, F. Keskin
Internal cooperation: W. Wölwer, J. Zielasek,
C. Lange-Asschenfeldt, U. Henning, W. Gaebel, A. Klimke,
HW. Müller, C. Antke, R. Larisch, J. Thünker
External cooperation: University of Bochum: MW. Agelink,
J. Kornischka, G. Juckel, U. Sprick; University and Technical
University Munich: R. Grohmann, H. Hauner; University of
Dresden: C. Kirschbaum, University of Bremen: B. Kudielka,
University of Hanover: K. Kahl, Alexianer; Krefeld Hospital:
A. Horn, J. Hummes, H. Eich; Psychiatric Hospital Aalborg,
Denmark: P. Munk-Joergensen; Hospital General Carlos
Haya in Málaga, Spain: G. Orozco
Allergic exanthemas after treatment
with psychotropic drugs
J. Cordes, C. Lange-Asschenfeldt, D. Geßner, R. Grohmann
Project period: 1996–2008
Financing: departmental research budget
Allergic skin reactions are potentially severe complications
and in individual cases may have considerable consequences
for the duration of treatment and treatment compliance.
There is a lack of data about the risk of allergic reactions after
therapy with psychotropic drugs and the potential risk factors.
In the framework of the above mentioned project “Drug safety
in psychiatry”, 221 severe drug-induced allergic exanthemas
were reported from 1993 until 2003, making exanthemas the
third most frequent side effect. An analysis was performed
regarding the frequency of use of psychotropic drugs in this
sample dataset (Figure 20).
Antipsychotics (19 %)
Antidepressants (29 %)
102
Others (12 %)
Lithium carbonate (1 %)
Anti-epileptics,
mood stabilisers
(39 %)
View into the neurobiochemical research laboratory
Physical illness in mental disorders
J. Cordes, W. Gaebel, J. Zielasek, P. Munk-Joergensen
Project period: 2006–2009
Financing: departmental research budget, Pifzer Pharma
GmbH, Tanita Europe
This local sub-project of an international multi-centre quality
assurance programme to detect comorbidity in mental
disorders included a weekly assessment of the presence
of the metabolic syndrome in psychiatric inpatients. In
addition, an impedance assessment of the visceral fat index
(VFI) was performed. The dataset contains 225 males and
252 females with an average age of 43.1±14.5 years and
an average observation period of 12 weeks. An increase
in body weight and VFI and decrease in HDL was found at
4 weeks in a significantly higher proportion of males than
females. Higher age was associated with an increased
prevalence of cardiovascular risk factors, increased body
weight, elevated mean fasting blood glucose levels, increased
mean triglycerides levels and decreased levels of HDL. All
study participants showed a significant increase in mean
body weight, BMI, overweight, waist circumference, VFI
and triglycerides over 12 weeks. Correlations (Spearman´s
coefficient) were found between VFI and BMI, waist
circumference, triglycerides, fasting blood glucose and total
Figure 20: Relative frequency of individual psychopharmaceutical groups
as triggers of allergic skin reactions; Figure (modified) after Lange-
Asschenfeldt et al. Cutaneous adverse reactions to psychotropic drugs: data
from AMSP Multicenter Surveillance Program. J Clin Psychiatr 2009, 70:
1258-1265