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LVR-Klinikum Düsseldorf Hospital of the Heinrich-Heine University ...

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<strong>LVR</strong>-KLINIKUM DÜsseLDORF – hOsPITaL OF The heINRIch-heINe UNIVeRsITY DÜsseLDORF<br />

3.1 Department <strong>of</strong> Psychiatry and Psycho<strong>the</strong>rapy<br />

3.1.1 Research Networks<br />

During <strong>the</strong> reporting period, <strong>the</strong> <strong>LVR</strong>-<strong>Klinikum</strong> <strong>Düsseldorf</strong><br />

was a member or at <strong>the</strong> head <strong>of</strong> several countrywide or<br />

regional research networks. Worthy <strong>of</strong> specific mention here<br />

are <strong>the</strong> “Competence Networks in Medicine” which, since<br />

1999, have been funded by <strong>the</strong> German Federal Ministry for<br />

Education and Research (FMER) to improve cooperation<br />

between <strong>the</strong> leading research institutions in specific research<br />

areas (horizontal networking) and those providing routine<br />

care (vertical networking) for individual clinical pictures<br />

across all fields <strong>of</strong> medicine. The programme is designed<br />

to make a contribution to improving <strong>the</strong> treatment <strong>of</strong> people<br />

with clinical pictures characterised by high morbidity and/or<br />

mortality rates. The Competence Network on Schizophrenia<br />

was one <strong>of</strong> <strong>the</strong> (initially nine, now eighteen) federally-funded,<br />

countrywide competence networks. The network was<br />

essentially <strong>the</strong> brainchild <strong>of</strong> <strong>the</strong> Department <strong>of</strong> Psychiatry<br />

and Psycho<strong>the</strong>rapy <strong>of</strong> <strong>the</strong> <strong>Heinrich</strong>-<strong>Heine</strong> <strong>University</strong>, <strong>LVR</strong>-<br />

<strong>Klinikum</strong> <strong>Düsseldorf</strong>, toge<strong>the</strong>r with <strong>the</strong> Department <strong>of</strong><br />

Psychiatry and Psycho<strong>the</strong>rapy <strong>of</strong> <strong>the</strong> Ludwig-Maximilian<br />

<strong>University</strong>, Munich (H.-J. Möller) and, since its start in 1999,<br />

has been coordinated by <strong>the</strong> Network Headquarters at <strong>the</strong><br />

Department <strong>of</strong> Psychiatry and Psycho<strong>the</strong>rapy, <strong>LVR</strong>-<strong>Klinikum</strong>.<br />

The spokesperson for <strong>the</strong> competence network is W. Gaebel.<br />

In addition, <strong>the</strong> <strong>LVR</strong>-<strong>Klinikum</strong> <strong>Düsseldorf</strong> has also been linked<br />

with research projects within <strong>the</strong> Competence Networks on<br />

Depression and Suicidality and has participated in projects <strong>of</strong><br />

<strong>the</strong> Competence Network on Dementia. In close collaboration<br />

with <strong>the</strong> Competence Network programme, <strong>the</strong> FMER has<br />

set up o<strong>the</strong>r associated research funding programmes, in<br />

which <strong>the</strong> Department <strong>of</strong> Psychiatry and Psycho<strong>the</strong>rapy<br />

takes part. This allowed, for instance, corresponding brain<br />

banks from different Competence Networks to be pooled<br />

into a cross-illness brain bank that can be used as a<br />

reference centre for CNS disorders (BrainNet), with which<br />

<strong>the</strong> Department <strong>of</strong> Psychiatry and Psycho<strong>the</strong>rapy is linked<br />

as an Associate Satellite Centre. In order to work on joint<br />

legal, organisational and technical solutions to problems<br />

simultaneously facing a number <strong>of</strong> research associations, <strong>the</strong><br />

FMER set up <strong>the</strong> Telematics Platform for Medical Research<br />

Networks (TMF e. V.), which has since taken <strong>the</strong> legal form<br />

<strong>of</strong> a registered non-pr<strong>of</strong>it association. The Competence<br />

Network on Schizophrenia is, amongst o<strong>the</strong>rs, a member <strong>of</strong><br />

this “umbrella association” <strong>of</strong> medical research networks and<br />

toge<strong>the</strong>r with o<strong>the</strong>r neuropsychiatric competence networks<br />

has attracted project funding for <strong>the</strong> creation <strong>of</strong> interfaces<br />

for exchanging data between clinical documentation systems<br />

58<br />

from <strong>the</strong> TMF. Finally, when <strong>the</strong> second funding period for<br />

<strong>the</strong> Competence Network on Schizophrenia ended in 2005, a<br />

countrywide research network for “Psycho<strong>the</strong>rapy in Positive<br />

Symptoms” (POSITIVE) was set up, which was conceived and<br />

initiated by <strong>the</strong> Tübingen <strong>University</strong> <strong>Hospital</strong> (S. Klingberg<br />

and G. Buchkremer) in close collaboration with cooperation<br />

partners from <strong>the</strong> Competence Network on Schizophrenia,<br />

including <strong>the</strong> network headquarters, and which has been<br />

coordinated by colleagues from Tübingen since its approval in<br />

2006. The Department <strong>of</strong> Psychiatry and Psycho<strong>the</strong>rapy is an<br />

active participant in almost all <strong>of</strong> <strong>the</strong>se research association<br />

projects. In <strong>the</strong> area <strong>of</strong> dependence and basic research, <strong>the</strong><br />

DFG Priority Programme 1226 “Nicotine: Molecular and<br />

Physiological Effects on <strong>the</strong> Central Nervous System” has<br />

been coordinated since 2006 at <strong>the</strong> <strong>LVR</strong>-<strong>Klinikum</strong> <strong>Düsseldorf</strong><br />

with G. Winterer as <strong>the</strong> spokesperson. He initiated <strong>the</strong><br />

programme, has contributed various projects and has<br />

participated in o<strong>the</strong>r projects. The objective <strong>of</strong> <strong>the</strong>se partially<br />

multi-site projects was <strong>the</strong> elucidation <strong>of</strong> <strong>the</strong> moleculargenetic<br />

principles <strong>of</strong> <strong>the</strong> effects <strong>of</strong> nicotine and nicotine<br />

dependence, as well as <strong>the</strong> neurobiological and clinical<br />

effects <strong>of</strong> nicotine. Moreover, <strong>the</strong> <strong>LVR</strong>-<strong>Klinikum</strong> <strong>Düsseldorf</strong><br />

was part <strong>of</strong> <strong>the</strong> Dependence Research Network North Rhine-<br />

Westphalia, initially conceived and managed by <strong>the</strong> <strong>LVR</strong>-<br />

<strong>Klinikum</strong> Essen. The <strong>LVR</strong>-<strong>Klinikum</strong> <strong>Düsseldorf</strong> contributed<br />

an own multi-centre project to this network and assumed its<br />

leadership in 2006.<br />

3.1.1.1 Competence Network on Schizophrenia (FMER)<br />

Spokesperson: W. Gaebel<br />

Network Headquarters: W. Wölwer, V. Toeller (from 2005),<br />

L. Freimüller (from 2008), S.-K. Schul<strong>the</strong>is (2005–2007),<br />

T. Ferrari (2003–2006), A. Weßling (until 2005)<br />

The Competence Network’s objectives<br />

The main concern <strong>of</strong> <strong>the</strong> Competence Network on<br />

Schizophrenia is <strong>the</strong> creation <strong>of</strong> scientific prerequisites for<br />

<strong>the</strong> optimisation <strong>of</strong> <strong>the</strong> prevention, acute and long-term<br />

treatment, and <strong>the</strong> rehabilitation <strong>of</strong> schizophrenic disorders.<br />

Contributions will be made to <strong>the</strong> following concrete<br />

objectives by means <strong>of</strong> practice-related and networked<br />

research projects and measures for health education:

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