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long-term intervention of psychoeducation, cognitive training and cognitive behavioural therapy plus information for relatives over 12 months. These methods were applied as described in a manual in a randomised study design within the framework of the pharmacotherapeutic basic study. No major differences were found between the two treatment arms in the following outcome parameters: clinically relevant worsening, several psychopathological and testpsychological scales. Only the drop-out rate was significantly increased in the cognitive-behavioural therapy arm of the study. When interpreting the results, one has to consider the self-levelling (positive) effects of pharmacotherapy, “ceiling effects” in regard to the positive selection of persons with a high degree treatment compliance and the longer duration of the cognitive-behavioural therapy arm with the associated higher likelihood of drop-out. S3 – Schizophrenia treatment guideline W. Gaebel, S. Weinmann Project period: 2001–2006 Financing: DGPPN and departmental research budget Under the aegis of the German Association for Psychiatry and Psychotherapy (DGPPN) and within the context of the guidelines/quality assurance section of the DGPPN (project manager: W. Gaebel), a new treatment guideline on the diagnosis and treatment of persons with schizophrenia was developed and published (see also Research Group on Quality Assurance in Psychiatry). With the participation of the Association of the Scientific Medical Societies in Germany (AWMF), the highest quality level of guideline development (S3) was followed which took into consideration all the elements of a systematic development (evidence-based medicine, achieving formal consent, algorithms, decision analysis and outcome analysis). Thus, knowledge about the (long-term) treatment of persons with schizophrenia is summarised on a high-quality foundation and made available as guideline recommendations to those working in clinical practice to support their decision-making and thus improve the quality of healthcare. ReseaRch Transfer of scientific knowledge from the Competence Network on Schizophrenia to healthcare practice: optimisation of healthcare for persons with first-episode schizophrenia (transfer module/TM II) Director: W. Gaebel Assistant: B. Conradt, M. Riesbeck, R. Zemlicka in cooperation with H.-J. Möller (Psychiatric Department of the Ludwig-Maximilian University Munich); J. Klosterkötter (Department of Psychiatry and Psychotherapy, University of Cologne); S. Klingberg (University Department of Psychiatry and Psychotherapy,f Tübingen) Project period: 2006–2010 Financing: FMER funding 01 GI 0502 On the basis of the results of the above mentioned firstepisode study (pharmacological acute and long-term treatment, psychological interventions) and in cooperation with the research projects for early recognition of firstepisode schizophrenia, various structural and procedural measures were developed and implemented in healthcare practice to improve the treatment of persons with firstepisode schizophrenia, especially in the early phases of incipient schizophrenia. A central goal of optimised healthcare is – besides improving early recognition and affording the earliest possible treatment of incipient schizophrenia – to retain persons with first-episode schizophrenia for the longest possible period of time on a by and large effective therapy with a low degree of side effects. To this end, a variety of information material was made available – mainly to mental healthcare professionals – through various types of media (papers, workshops, seminars), providing information about the evidencebased knowledge on increasing adherence to therapy in particular. At the centre of the project is a practice manual, in which the characteristics of the treatment of persons with first-episode schizophrenia are explained, and the establishment of specially qualified treatment centres, which offer optimised therapy to persons with first-episode schizophrenia. These centres should be able to provide expert knowledge in pharmacotherapy and psychological methods and should guarantee the continuity of treatment across diverse healthcare sectors (inpatient, day care, outpatient). 93
LVR-KLINIKUM DÜsseLDORF – hOsPITaL OF The heINRIch-heINe UNIVeRsITY DÜsseLDORF 5-year follow-up of the study “Pharmacotherapeutic strategies for the prevention of relapse in persons with first-episode schizophrenia” to identify prognostic indicators for the course of the illness Director: W. Gaebel Assistant: R. Zemlicka in cooperation with University Psychiatry Departments at Berlin, Bonn, Essen, Göttingen, Halle, Jena, Köln, Mannheim, Munich and Tübingen Project period: 2006–2009 Financing: FMER funding 01 GI 0502 As was described in the section on the first-episode longterm study (see above), more than 70% of the patients discontinued treatment prematurely. Of the more than 300 individuals included in the acute study, only approximately 70 could be followed over at least one year. A presumed (strong) selection bias considerably impaired disease course prognosis and the identification of course indicators, 94 especially regarding the generalisability of the results of this research project. Therefore, this project aimed at a 5-year follow up of the ca. 650 persons with schizophrenia from among the ca. 1370 who had been screened, to determine the therapeutic success and disease course of the persons who had been treated in the first-episode study. Further aims of the study were quality management and to identify valid risk indicators for non-response to therapy or an unfavourable disease course in persons with first-episode schizophrenia. The research project was mainly supported by our local working group with additional support by those study centres that had participated in the first-episode study, in particular with regard to contacting the persons who had participated in the first-episode study and admitting them for follow-up. However, the study was prematurely terminated because the vast majority of study participants could not be motivated to attend a follow-up investigation. Facial affect decoding training significantly improves the identification of emotions in a face
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LVR Landschaftsverband Rheinland LV
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LVR-KLINIKUM DÜSSELDORF - HOSPITAL
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lVR-KliniKum DÜSSelDoRF - HoSPitAl
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2. Healthcare
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Table 1: Number of inpatients of th
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The Day Care Unit House 20 of the D
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P 1 P 37 5 38 2 39 P P P P P P Hous
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persons - several target syndromes
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The Division of General Psychiatry
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Conversations with family members p
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doctors of the Düsseldorf Universi
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people are admitted following inpat
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multiprofessional, qualified treatm
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s Cerebral epileptic seizures, for
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flat, providing space for a total o
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2.2.1.7 Current Scientific and Acad
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2002 Gaebel W, Müller U (2002): St
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3.1.11 Organised science symposia a
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s From 2009-2010 Member of the WHO
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3.2.1.2 Psychodiabetology Director:
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3.2.1.5 Psychooncology Director: J.
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3.2.2 Doctoral dissertations and ha
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Schmitz N, Kruse J, Tress W (2001):
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Simson U, Martin K, Schäfer R, Jan
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Kulzer B, Albus C, Herpertz S, Krus
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Wöller W, Bernard J, Kruse J, Bass
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2006 Kruse J, Wöller W (2006): Psy
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2003 Kruse J (2003): Arzt-Patient-K
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Psychosomatic intervention for pati
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3.2.6 Personnel Tress, Wolfgang Mem
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PRECONDIS-study: Parent training fo
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The scientific library of the LVR-K
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Klinikum Düsseldorf works closely
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