LVR-Klinikum Düsseldorf Hospital of the Heinrich-Heine University ...

cholesterol. These results demonstrate the negative effects
of inpatient treatment on cardiovascular risk factors and
metabolic parameters.
Influence of psychosocial burden, alcohol detoxification
and hypothyreosis on saliva cortisol levels
J. Thünker, J. Cordes, A. Klimke, P. Messinger,
C. Kirschbaum, B. Kudielka, U. Henning, M. Warnecke,
L. Kostorz, R. Larisch, HW. Müller, C. Antke, M. Woite
Project period: 2005–2010
Financing: departmental research budget, Servier Pharma
Nineteen healthy controls and 32 persons with partially
remitted depression were studied. The Trier Social Stress
Test was used as a social stressor, in which after a short
preparation time a free speech of a few minutes duration
has to be delivered. Cortisol, noradrenaline and dopamine
were measured before and 10, 20, 30, 45 and 60 minutes
after the test. In addition, study participants completed five
self-rating scales including the Measure to Assess Stress
Proneness (MESA) and the Trier Inventory to Measure
Chronic Stress (TICS). The BDI was used to assess levels of
depression. When both groups were compared, differences
were found in depression scores (t(35)=3.177, p=0.003);
stress proneness (MESA, t(37)=2.153, p=ß.038); the two
subscales of the TICS, “sorrows” (t(35)=2.135, p=0.040)
and “burdening memories” (t(35)=2.297, p=0.028); and the
neuroendocrinological parameter noradrenaline (F(1)=5.283,
p=0.030). Correlations between neurophysiological and
psychological measures were found for dopamine and the
sleepiness scale of the multidimensional mental state scale
(MDBF; r