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3.1.2.2 Experimental Psychopathology Research Laboratory Directors: W. Wölwer, W. Gaebel Scientific personnel: N. Frommann, S. Stroth (from 2008), K. Drusch (from 2009), S. Beulen (from 2009), K. Fisahn (2008-2009), F. Lüneborg (from 2008), A. Witt (2007-2009), S. Kiszkenow (from 2007), M. Memmou (2007–2009), M. Weickert (2006–2009), B. Lindel (2006–2007), S. Halfmann (2004–2006), M. Streit (until 2003) Non-scientific personnel: P. Pitters The focus of the research laboratory’s work is essentially related to cognitive and emotional-affective impairments in schizophrenic psychoses as well as – based upon this – related to the development of a functional diagnostic approach to psychopathology. Within this context, neuropsychological predictors of relapse in schizophrenia and alcohol dependency are investigated in more detail, and rehabilitative interventions for cognitive impairments in schizophrenia are developed and evaluated. In addition, the research laboratory is active in national multi-centre evaluation studies on cognitive behavioural therapy in people with schizophrenia. The Department cooperated closely with the “Long-term Treatment of Schizophrenic Psychoses”, “Dependence Disorders” and “Transcranial magnetic stimulation” research groups, as well as the Neuropsychiatry Research Laboratory. Cooperation s H. Ellgring, Institute of Psychology, University of Würzburg: Objective evaluation of expression characteristics in schizophrenia ReseaRch s P. Falkai, Department of Psychiatry and Psychotherapy, University of Göttingen: Neuropsychological and brain-morphology investigations in people with alcohol dependence and in relatives of patients with schizophrenia s G. Fink, J. Shah, Jülich Research Centre: Brain-imaging correlates of social-cognitive processes and the effects of nicotine on these processes s U. Habel, F. Schneider, Department of Psychiatry and Psychotherapy, RWTH Aachen: Brain-imaging correlates of social-cognitive rehabilitation in people with schizophrenia s S. Klingberg, Department of Psychiatry and Psychotherapy, University of Tübingen: Evaluation of Cognitive Behavioural Therapy in people with schizophrenia s V. Larach Walters, Andres Bello University, Faculty of Medicine, Department of Psychiatry, Santiago, Chile: Expression characteristics in people with schizophrenia undergoing antipsychotic treatment s W. Schmidbauer, Forensic Psychiatry Department, Haina: Evaluation of social-cognitive rehabilitation in forensic psychiatry patients with schizophrenia s R. Vauth, Department of Psychiatry and Psychotherapy, University of Basel: Rehabilitation strategies in socialcognitive impairments in people with schizophrenia s M. Wagner, Department of Psychiatry and Psychotherapy, University of Bonn: Neuropsychological investigation in people with schizophrenia and persons at risk for schizophrenia. In addition, within the Competence Network on schizophrenia and the POSITIVE Psychotherapy Research The Team of the Experimental Psychopathology Research Laboratory 73
LVR-KLINIKUM DÜsseLDORF – hOsPITaL OF The heINRIch-heINe UNIVeRsITY DÜsseLDORF Network, there are close links with a lot of other working groups, based on joint participation in multi-centre projects. Projects Neuropsychological relapse predictors in persons with alcohol dependence Sub-project of the study “Acamprosat and integrative behavioural therapy in the outpatient treatment of alcohol dependency” (Principal investigator: W. Gaebel) W. Wölwer, W. Gaebel in cooperation with the Dependence Disorders research group Project period: 2002–2007 Financing: FMER funding 01 EB 0133 Although cognitive disorders in people with alcohol dependence have been known for a long time, the question of the interaction of such disorders with the treatment process is still relatively unclear because of conflicting results. Some findings from a previous study in 120 patients with alcohol dependence, who, after inpatient detoxication, were randomly assigned to one of three six-month outpatient psychotherapy conditions, indicate that those patients 74 Assessment of the electrophysiological correlates of facial affect decoding in the Experimental Psychopathology Research Laboratory relapsing already within this treatment period – independent of the treatment – demonstrated more pronounced cognitive impairments (particularly in verbal memory and visualmotor functions) already before they entered the treatment than patients remaining abstinent. This finding could only partially be confirmed within the context of the present project involving 371 persons with alcohol dependence, who, after detoxification, were randomly assigned to one of three six-month combination treatments with medication and psychotherapy components (anti-craving medication plus cognitive behavioural therapy or plus consultations during ward rounds, or placebo plus cognitive behavioural therapy). Cognitive impairments had an impact, particularly in the sense of a reduced rate of successful treatment completions, if the anti-craving substance (acamprosat) was used without accompanying cognitive behavioural treatment. However, no predictive effect of cognitive impairments was identifiable under the two strategies based on behavioural therapy, possibly because the therapists had intuitively matched the psychotherapy in individual settings to the patients’ individual deficits and resources.
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LVR Landschaftsverband Rheinland LV
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2. Healthcare
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Table 1: Number of inpatients of th
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The Day Care Unit House 20 of the D
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Kratz S, Härter M, Bermejo I, Berg
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2005 Baumann AE, Richter K, Belevsk
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Weinmann S, Janssen B, Gaebel W (20
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115-121 Wölwer W, Gaebel W (2006):
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Winterer G, Carver FW, Musso F, Mat
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Luckhaus C, Grass-Kapanke B, Blaese
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from a naturalistic study on a larg
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3.1.9.2 Book contributions 2001 Gae
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Schneider F, Habel U (2002): Emotio
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2006 Baumann A (2006): Stigmatisier
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2002 Gaebel W, Müller U (2002): St
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3.1.11 Organised science symposia a
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s From 2009-2010 Member of the WHO
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3.2.1.2 Psychodiabetology Director:
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3.2.1.5 Psychooncology Director: J.
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3.2.2 Doctoral dissertations and ha
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Schmitz N, Kruse J, Tress W (2001):
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Simson U, Martin K, Schäfer R, Jan
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Kulzer B, Albus C, Herpertz S, Krus
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Wöller W, Bernard J, Kruse J, Bass
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2006 Kruse J, Wöller W (2006): Psy
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2003 Kruse J (2003): Arzt-Patient-K
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PRECONDIS-study: Parent training fo
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Klinikum Düsseldorf works closely
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