LVR-Klinikum Düsseldorf Hospital of the Heinrich-Heine University ...

More documents

Recommendations

Info

Cognitive behaviour therapy for the treatment of negative symptoms in schizophrenia (TONES) Participation in the homonymous, multi-centric project (Principal investigator: S. Klingberg, University of Tübingen) W. Wölwer, N. Frommann, S. Halfmann, M. Memmou, M. Weickert Project period: 2005–2009 Financing: DFG funding KL 1179/3-1 to Klingberg, Tübingen Since to date negative symptoms in schizophrenia often cannot be satisfactorily treated with the available drug and psychotherapeutic strategies, this project investigates whether these symptoms can be reduced by means of a cognitive behaviour therapy (CBT) specifically adjusted to meet the needs of such patients. A newly designed variant of CBT was compared with a cognitive remediation treatment over 20 sessions, distributed over 9 months of treatment, within the context of a controlled randomised clinical trial in 198 patients. In 2008, full recruitment of 66 patients at each of the three participating centres (the University Psychiatry Departments of Tübingen, Düsseldorf and Frankfurt) could be achieved and the nine-month treatment could be concluded in almost all patients. The project is currently in the phase of statistical analysis. Cognitive behaviour therapy in the treatment of positive symptoms in psychotic disorders (POSITIVE) Participation in the homonymous, multi-centre project within the POSITIVE Psychotherapy Research Network (Principal investigator: S. Klingberg, University of Tübingen) W. Wölwer, S. Kiszkenow, A. Witt, S. Beulen Project period: 2006–2010 Financing: FMER funding 01 GV 0618 to S. Klingberg, Tübingen New psychotherapy research – particularly from the UK – provides evidence that cognitive behavioural therapy can be used successfully to reduce previously persistent symptoms. This project, in addition to replicating such findings in the German language area, aims to provide an explanation of the mechanisms of effect. According to current psychological models relating to the development and persistence of psychotic symptoms, these mechanisms include, amongst other things, a change of defined cognitive biases and are not only be based on unspecific factors that do not depend on treatment forms. To shed light on this question, the effect of cognitive behavioural therapy (CBT) versus supportive therapy (ST) on psychopathological symptoms and neuropsychological indicators of cognitive biases is being investigated in a multi-centre, randomised, controlled study. A total of 163 patients will be included in each treatment condition, which comprises 20 sessions of 50 minutes in an outpatient setting over a period of nine months. Follow-up ReseaRch assessments will be carried out four times over two years to check the stability of the achieved effects. By the end of 2009, 326 of the total planned recruitment number of 330 patients had been included into the study. Threat-sensitivity in patients with psychotic disorders: behaviour indicators and neuronal correlates Sub-project of the studies “Cognitive biases as a basis for delusion symptoms and their alteration with a cognitive behavioural therapy in patients with psychotic disorders” (Principal investigator: W. Wagner, University of Bonn) and “Multi-centre fMRT-study of the neuronal correlates of a cognitive behavioural therapy in patients with psychotic disorders” (Principal investigator: T. Kircher, RWTH Aachen/ University of Marburg) within the POSITIVE Psychotherapy Research Network W. Wölwer, J. Brinkmeyer, S. Kiszkenow in cooperation with the Neuropsychiatry Research Laboratory (G. Winterer) and the Department for Neuroradiology Project period: 2006–2010 Financing: FMER funding to M. Wagner, Bonn and T. Kircher, Aachen/Marburg This project addresses the higher sensitivity for threatening stimuli in psychotic disorders with symptoms of delusion, as supposed in the literature, and the neurobiological basis of this cognitive bias. An increased sensitivity to being threatened is part of the cognitive biases that contribute to the current psychological models for the development and persistence of psychotic symptoms. A paradigm, developed in our research laboratory, for assessing the sensitivity to being threatened is being used in the neuropsychological sub-project being carried out at all centres and with all patients in the previously described clinical psychotherapy trial. In addition, the paradigm is also being used during an fMRI assessment of selected study patients of the LVR- Klinikum. 79
LVR-KLINIKUM DÜsseLDORF – hOsPITaL OF The heINRIch-heINe UNIVeRsITY DÜsseLDORF 3.1.2.3 Brain morphology research laboratory and animal experimental psychosis research Director: M. von Wilmsdorff (from 2002), U. Sprick (until 2002) Scientific personnel: M.-L. Bouvier The brain morphology and animal experimental schizophrenia research laboratory focused on the development of a new animal model which ascribes the aetiology of schizophrenia to disturbances during prenatal brain development. Since 2003, the laboratory’s research work has been extended to the effects of antipsychotic drugs on somatic control systems in the animal model. Here, on the one hand, the influence of typical and atypical antipsychotic drugs on the secretion of leptin into the blood and the regulation of hypothalamic leptin receptors was investigated. A second project aimed to explain how typical and atypical antipsychotic drugs influence metabolic parameters of the metabolic syndrome. 80 Evaluating tests results in the histological laboratory Projects Prenatal excitotoxic damage of the hippocampus in rats as a model of schizophrenia Project period: 1998–2002 Financing: Departmental research budget On the basis of the results of epidemiological studies and the hypothesis that disorders in prenatal neurodevelopment in humans may lead to schizophrenia after puberty, the study investigates for the first time the influence of damage to the hippocampus during the foetal period in rats. The damaging agents are applied in the time interval that corresponds to the second trimester of pregnancy in humans, a time period that is particularly sensitive to neuronal defects. The behaviour of the rats administered kainic acid prenatally into the intracerebral ventricles was compared with that of untreated animals in several sets of tests over a period of six months. The assessments included changes in weight, motor coordination and spontaneous locomotion, working memory deficits, the development of
Page 1 and 2:
LVR Landschaftsverband Rheinland LV
Page 3 and 4:
LVR-KLINIKUM DÜSSELDORF - HOSPITAL
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
lVR-KliniKum DÜSSelDoRF - HoSPitAl
Page 13 and 14:
Page 15 and 16:
Page 18 and 19:
2. Healthcare
Page 20 and 21:
Table 1: Number of inpatients of th
Page 22 and 23:
The Day Care Unit House 20 of the D
Page 24 and 25:
P 1 P 37 5 38 2 39 P P P P P P Hous
Page 26 and 27:
persons - several target syndromes
Page 28 and 29:
The Division of General Psychiatry
Page 30 and 31: Conversations with family members p
Page 32 and 33: doctors of the Düsseldorf Universi
Page 34 and 35: people are admitted following inpat
Page 36 and 37: multiprofessional, qualified treatm
Page 38 and 39: s Cerebral epileptic seizures, for
Page 40 and 41: flat, providing space for a total o
Page 42 and 43: 2.2.1.7 Current Scientific and Acad
Page 44 and 45: The psychotherapeutic treatment con
Page 46 and 47: 2.2.3 Division of Child and Adolesc
Page 48 and 49: therapy), trauma therapy (for examp
Page 50 and 51: documenting all types of nursing in
Page 52 and 53: Other diagnostic techniques s Compu
Page 54 and 55: Social services Coordinator: Christ
Page 56 and 57: for medical reports and the request
Page 58 and 59: 3. Research ReseaRch
Page 60 and 61: s Early diagnosis of persons with a
Page 62 and 63: Table 3: Research projects of the C
Page 64 and 65: No. Project Participating research
Page 66 and 67: No. Project Participating research
Page 68 and 69: cells, the cultivation of which was
Page 70 and 71: Since agranulocytosis usually occur
Page 72 and 73: predisposition factors, which affec
Page 74 and 75: 3.1.2.2 Experimental Psychopatholog
Page 76 and 77: Clinical symptom index More symptom
Page 78 and 79: Brain-imaging correlates of therape
Page 82 and 83: specific anxiety behaviour and asso
Page 84 and 85: 3.1.2.4 Psychophysiology and Psycho
Page 86 and 87: s D. Durstewitz, Centre for Theoret
Page 88 and 89: Influence of the m-opioid receptor
Page 90 and 91: 3.1.3.2 Dependence disorders Direct
Page 92 and 93: investigations of different questio
Page 94 and 95: long-term intervention of psychoedu
Page 96 and 97: 3.1.3.4 Destigmatisation of people
Page 98 and 99: 3.1.3.5 Gerontopsychiatry and demen
Page 100 and 101: Burst rate 140 120 100 80 60 40 20
Page 102 and 103: Within the “Active approach consu
Page 104 and 105: cholesterol. These results demonstr
Page 106 and 107: eceived only brief information abou
Page 108 and 109: egarding compiling quality-related
Page 110 and 111: Effectiveness of rTMS in persons wi
Page 112 and 113: Repetitive transcranial magnetic st
Page 114 and 115: 3.1.5 Research Centres 3.1.5.1 Clin
Page 116 and 117: Investigation of the clientele of
Page 118 and 119: s Archiving study documents s Suppo
Page 120 and 121: 3.1.8 Diploma and master theses, do
Page 122 and 123: Leweke M, Mangholz A, Massing W, Me
Page 124 and 125: Kratz S, Härter M, Bermejo I, Berg
Page 126 and 127: 2005 Baumann AE, Richter K, Belevsk
Page 128 and 129: Weinmann S, Janssen B, Gaebel W (20
Page 130 and 131:
115-121 Wölwer W, Gaebel W (2006):
Page 132 and 133:
Winterer G, Carver FW, Musso F, Mat
Page 134 and 135:
Luckhaus C, Grass-Kapanke B, Blaese
Page 136 and 137:
from a naturalistic study on a larg
Page 138 and 139:
3.1.9.2 Book contributions 2001 Gae
Page 140 and 141:
Schneider F, Habel U (2002): Emotio
Page 142 and 143:
2006 Baumann A (2006): Stigmatisier
Page 144 and 145:
2002 Gaebel W, Müller U (2002): St
Page 146 and 147:
3.1.11 Organised science symposia a
Page 148 and 149:
s From 2009-2010 Member of the WHO
Page 150 and 151:
3.2.1.2 Psychodiabetology Director:
Page 152 and 153:
3.2.1.5 Psychooncology Director: J.
Page 154 and 155:
3.2.2 Doctoral dissertations and ha
Page 156 and 157:
Schmitz N, Kruse J, Tress W (2001):
Page 158 and 159:
Simson U, Martin K, Schäfer R, Jan
Page 160 and 161:
Kulzer B, Albus C, Herpertz S, Krus
Page 162 and 163:
Wöller W, Bernard J, Kruse J, Bass
Page 164 and 165:
Ott J, Kruse J, Tress W (2003): Das
Page 166 and 167:
2006 Kruse J, Wöller W (2006): Psy
Page 168 and 169:
2003 Kruse J (2003): Arzt-Patient-K
Page 170 and 171:
Psychosomatic intervention for pati
Page 172 and 173:
3.2.6 Personnel Tress, Wolfgang Mem
Page 174 and 175:
PRECONDIS-study: Parent training fo
Page 176:
The scientific library of the LVR-K
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191:
Klinikum Düsseldorf works closely
show all

LVR-Klinikum Düsseldorf Hospital of the Heinrich-Heine University ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?