Participación del Factor Silenciador Neuronal Restrictivo - Tesis ...

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REFERENCIAS 117 Alexandre C, Jacinto A & Ingham PW. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the Gli family of zinc finger DNA binding proteins. Genes Dev. 10: 2003- 2013. Andreazzoli M, Gestri G, Cremisi F, Casarosa S, Dawid IB & Barsacchi G. (2003). Xrx1controls proliferation and neurogenesis in Xenopusanterior neural plate. Development 130: 5143-5154 Andres ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, & Mandel G. (1999). CoREST: a functional corepressor required for regulation of neural- specific gene expression. Proc. Natl. Acad. Sci. U.S.A 96: 9873- 9878. Armisén R, Fuentes R, Olguín P, Cabrejos ME & Kukuljan M. (2002). Repressor Element-1 Silencing Transcription/Neuron-Restrictive Silencer Factor Is Required for Neural Sodium Channel Expression during Development of Xenopus. J. Neurosci. 22: 8347–8351. Ault KT, Xu RH, Kung HF, Jamrich M. (1997). The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos. Dev. Biol. 192: 162-171. Aybar M & Mayor R. (2002). Early induction of neural crest cells: lessons learned from frog, fish, and chick. Curr. Opin. Genet. Dev. 12: 452-458. Bachiller D, Klingensmith J, Shneyder N, Anderson R, Tran U, et al. (2000). The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403: 658–61. Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, et al. (2003). The role of chordin/BMP signals in mammalian pharyngeal development and DiGeorge syndrome. Development 130:3567–78. Bainter J, Boos A, and Kroll K. (2001). Neural induction takes a transcriptional twist. Dev. Dyn. 222: 315-327. Baker JC, Beddington RS, Harland RM. (1999). Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev. 13:3149–59. Baker NE & Yu SY. (1997). Proneural function of neurogenic genes in the developing Drosophila eye. Curr. Biol. 7: 122–132. Ballas N & Mandel G. (2005). The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol. 15: 500-506.
118 Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ et al. (2001). Regulation of neuronal traits by a novel transcriptional complex. Neuron 31: 353-365. Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. (2005). REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121: 645-657. Barth KA, Kishimoto Y, Rohr KB, Seydler C, Schulte-Merker S and Wilson SW. (1999). BMP activity establishes a gradient of positional information throughout the entire neural plate. Development 126: 4977-4987. Bei M & Maas R. (1995). FGFs and BMP4 induce both Msx1-independent and Msx1dependent signaling pathways in early tooth development. Development 125: 4325-33. Bellefroid E, Bourguignon C, Hollemann T, Ma Q, Anderson DJ & Pieler T. (1996). X- MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87: 1191-1202. Bellefroid E, Kobbe A, Gruss P, Pieler T, Gurdon JB & Papalopulu N. (1998). Xiro3 encodes a Xenopus homolog of the Drosophila iroquois genes and functions in neural specification. EMBO J. 17: 191-203. Bernier G, Panitz F, Zhou X, Hollemann T, Gruss P & Pieler T. (2000). Expanded retina territory by midbrain transformation upon overexpression of Six6(Optx2) in Xenopusembryos. Mech. Dev. 93: 59-69. Bertrand N, Castro DS & Guillemot F. (2002). Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3: 517-530. Bessis A, Champtiaux N, Chatelin L & Changeux JP. (1997). The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain. Proc. Natl. Acad. Sci. U.S.A 94: 5906-5911. Blum M, Gaunt SJ, Cho KW, Steinbeisser H, Blumberg B, Bittner D & De Robertis EM. (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69: 1097-1106. Born J, Janeczek J, Schwarz W & Tiedemann H. (1989). Activation of masked neural determinants in amphibian eggs and embryos and their release from the inducing tissue. Cell Differ. Dev. 27: 1-7. Bourguignon C, Li J and Papalopulu N. (1998). XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm. Development 125: 4889-4900.
Page 1 and 2:
Universidad de Chile, Facultad de M
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Quisiera agradecer muy especialment
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Hipótesis……………………
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6. Función de XCoREST en el la esp
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Índice de figuras Figura 1. Experi
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Lista de publicaciones - Olguín P,
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embriones de Xenopus desde la blás
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laevis the ectoderm is patterned at
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Posteriormente, en otros vertebrado
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1.3 Inductores neurales y vías de
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formación de la placa neural y la
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Figura 3. Modelos de inducción neu
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destinos dependiendo de su localiza
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16 Figura 4. Modelo de doble gradie
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3.2 Neurogénesis primaria en Xenop
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adoptar el destino neural para fina
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neuronas ectópicas cuando es sobre
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Skarmeta et al., 1996) . Zic2 supri
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etrasan la diferenciación neuronal
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genes reporteros (ej. lacZ) que con
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manifiestan en la desacetilación d
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(Ballas et al., 2005) (Figura 11).
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corticales aislados y tratados con
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4.2.4 Función de REST/NRSF en neur
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1/NRSE mutado se expresa en gran pa
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silvestres. Sin embargo, en estadio
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tejido neural, como también en la
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participar en la neurogénesis a tr
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-Pinzas nº 5 (A. DUMONT y FILS, Su
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-MEMPFA (MOPS 0,1 M pH 7,0 EGTA 2 m
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-Bromuro de Etidio (GIBCO BRL, Cali
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concentración de mRNA a inyectar s
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Recolección de embriones. Para el
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Técnicas de Biología Molecular. A
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histona H3 fosforilada (Upstate) en
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Síntesis de ribosondas para hibrid
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Hibridación in situ (ISH). Los emb
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RESULTADOS 1. Clonamiento del cDNA
Page 77 and 78: Figura 14. Alineamiento de la secue
Page 79 and 80: 3. Participación de XREST/NRSF en
Page 81 and 82: Figura 16. La interferencia de la f
Page 83 and 84: 3.2 La interferencia de la función
Page 85 and 86: 74 Figura 17. La interferencia de l
Page 87 and 88: 4. Participación de XREST/NRSF en
Page 89 and 90: Figura 19. La interferencia de la f
Page 91 and 92: 4.2 La sobreexpresión de XREST/NRS
Page 93 and 94: 4.3 Los fenotipos ectodérmicos aso
Page 95 and 96: 4.4 La sobreexpresión de XREST1 no
Page 97 and 98: 4.5 La interferencia de la función
Page 99 and 100: 4.6 XREST/NRSF participa en la form
Page 101 and 102: Figura 24. Los fenotipos asociados
Page 103 and 104: Para poner a prueba esta idea se co
Page 105 and 106: 6. XCoREST participa en el establec
Page 107 and 108: Figura 26. XCoREST participa en el
Page 109 and 110: 1. XREST/NRSF regula la expresión
Page 111 and 112: 100 2. La interferencia de la funci
Page 113 and 114: 102 actividad de Wnt y FGF inducen
Page 115 and 116: 104 letalidad, probablemente porque
Page 117 and 118: 106 XREST/NRSF neuraliza los explan
Page 119 and 120: 108 mutada en los dominios de fosfo
Page 121 and 122: 110 5. XREST/NRSF modula la adquisi
Page 123 and 124: 112 cuenta de un potencial de acci
Page 125 and 126: 114 al neuroectodermo. La inhibici
Page 127: 116 embargo, estos resultados deben
Page 131 and 132: 120 Chitnis AB. (1999). Control of
Page 133 and 134: 122 Godsave SF and Slack JM. (1989)
Page 135 and 136: 124 Kallunki P, Edelman GM & Jones
Page 137 and 138: 126 Luther WH. (1935). Entwicklungs
Page 139 and 140: 128 Oppenheimer JM. (1936b). Transp
Page 141 and 142: 130 Spemann H & Mangold H. (1924).
Page 143 and 144: 132 Wilson PA, Hemmati-Brivanlou A.
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Participación del Factor Silenciador Neuronal Restrictivo - Tesis ...

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