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Libro de Resúmenes / Book of Abstracts (Español/English)

Libro de Resúmenes / Book of Abstracts (Español/English)

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Conferencias 9<br />

Algunos mo<strong>de</strong>los matemáticos <strong>de</strong> actividad eléctrica<br />

en neuronas y células cardiacas.<br />

Lucía Cervantes Gómez<br />

Facultad <strong>de</strong> Ciencias Físico Matemáticas<br />

B. Universidad Autónoma <strong>de</strong> Puebla. México<br />

lcervant@fcfm.buap.mx<br />

La mo<strong>de</strong>lación matemática <strong>de</strong> las células eléctricamente excitables,<br />

como son las células cardiacas y la mayoría <strong>de</strong> las neuronas, impone<br />

diferentes <strong>de</strong>safíos y proporciona distintos problemas matemáticos.<br />

En esta plática presentaré algunas <strong>de</strong> las situaciones que uno pue<strong>de</strong><br />

encontrar, en tres ejemplos <strong>de</strong> mo<strong>de</strong>lación <strong>de</strong> actividad eléctrica en células<br />

excitables.<br />

Empezaré con el ejemplo <strong>de</strong> la i<strong>de</strong>ntificación <strong>de</strong> parámetros en<br />

mo<strong>de</strong>los <strong>de</strong> corrientes iónicas transmembranales, comentando sobre las<br />

características <strong>de</strong> la i<strong>de</strong>ntificación <strong>de</strong> corrientes <strong>de</strong> calcio y <strong>de</strong>pendientes <strong>de</strong><br />

calcio.<br />

A continuación mostraré un mo<strong>de</strong>lo para el circuito neuronal más<br />

simple involucrado con alguna unidad <strong>de</strong> conducta, el cual es la vía <strong>de</strong>l<br />

reflejo monosináptico. Las fluctuaciones <strong>de</strong> la amplitud <strong>de</strong>l reflejo se<br />

simularon usando las soluciones <strong>de</strong>l mo<strong>de</strong>lo matemático para 100<br />

motoneuronas.<br />

Finalmente, para células cardiacas presentaré una reducción <strong>de</strong>l<br />

mo<strong>de</strong>lo <strong>de</strong> Luo Rudy, la cual reproduce las características principales <strong>de</strong> sus<br />

potenciales <strong>de</strong> acción.<br />

Mathematical mo<strong>de</strong>ls <strong>of</strong> electrical activity<br />

in neurons and cardiac cells<br />

The mathematical mo<strong>de</strong>ling <strong>of</strong> the electrically excitable cells, like the<br />

cardiac ones and the majority <strong>of</strong> the neurons, imposes different challenges<br />

and gives us different mathematical problems.<br />

In this talk I will present some <strong>of</strong> the situations which we could find in<br />

three mo<strong>de</strong>ling examples <strong>of</strong> electrical activity in excitable cells.<br />

I will start with the example <strong>of</strong> parameter i<strong>de</strong>ntification in mo<strong>de</strong>ls <strong>of</strong><br />

transmembranal ionic currents, giving an opinion about the features <strong>of</strong> the<br />

i<strong>de</strong>ntification <strong>of</strong> calcium currents and calcium <strong>de</strong>pen<strong>de</strong>nt currents.<br />

Secondly, I will show a mo<strong>de</strong>l for the simplest neural circuit that<br />

mediates some elementary unit <strong>of</strong> behavior, the monosynaptic reflex<br />

pathway. Amplitu<strong>de</strong> fluctuations <strong>of</strong> the monosynaptic reflexes were<br />

computed using the solutions <strong>of</strong> the mathematical mo<strong>de</strong>l for 100<br />

motoneurones.<br />

Finally, for cardiac cells I will present a reduction <strong>of</strong> the Luo Rudy’s<br />

mo<strong>de</strong>l, such reduced mo<strong>de</strong>l reproduces the principal features <strong>of</strong> their action<br />

potentials.

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