Libro de Resúmenes / Book of Abstracts (Español/English)
Libro de Resúmenes / Book of Abstracts (Español/English)
Libro de Resúmenes / Book of Abstracts (Español/English)
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Resumenes 140<br />
anti-inflammatory effect <strong>of</strong> different doses <strong>of</strong> a inmunomodulator via<br />
intrauterine (IU) administration was evaluated in the elimination <strong>of</strong> induced<br />
infectious endometritis with Streptococcus zooepi<strong>de</strong>micus.<br />
For this purpose a total <strong>of</strong> twenty-four mares were used in a two<br />
period crossover experimental <strong>de</strong>sign to evaluate 4 treatments (3 different<br />
doses and a control). The experimental <strong>de</strong>sign involved six mares per group<br />
in two periods (or phases), with 12 observations per treatment. Before<br />
treatment assignment, all mares were first diagnosed as free <strong>of</strong> any uterine<br />
bacterial infection, and then they were challenged with a standardized IU<br />
inoculum <strong>of</strong> live Streptococcus zooepi<strong>de</strong>micus to induce clinical<br />
endometritis. Experimental animals were divi<strong>de</strong>d into four equal groups. To<br />
assess the status <strong>of</strong> endometritis for each individual, ultrasonography<br />
<strong>de</strong>tection <strong>of</strong> intrauterine fluid, uterine swabs and biopsy samples were<br />
collected at four different points during the study. The efficacy <strong>of</strong> each<br />
treatment was evaluated by variables that were expressed as categorical<br />
data (culture positive or negative, biopsy gra<strong>de</strong>s between I and IV, positive<br />
or negative for uterine fluid, and exfoliative cytology positive or negative).<br />
All samples were analyzed, using PROC GENMOD procedure <strong>of</strong> Statistical<br />
Analysis Systems, Version 8 (SAS, Institute Inc.,Cary, NC, USA) to fit<br />
generalized linear mo<strong>de</strong>ls, using options DIST=BINOMIAL or<br />
DIST=MULTINOMIAL in the MODEL statement.<br />
Significant statistical differences were <strong>de</strong>tected in culture, biopsy and<br />
cytology (P0.05).<br />
This test has shown to be suitable for analysis <strong>of</strong> the mentioned<br />
experimental <strong>de</strong>sign.<br />
Keyword: mare endometritis, crossover <strong>de</strong>sign, generalized linear mo<strong>de</strong>l