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Libro de Resúmenes / Book of Abstracts (Español/English)

Libro de Resúmenes / Book of Abstracts (Español/English)

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Resumenes 179<br />

Malaria is the tropical infectious disease which menaces more people<br />

in the world than any other disease. The largest number <strong>of</strong> cases in America<br />

occurs in Brazil, being this one the third country in the disease inci<strong>de</strong>nce in<br />

the world. In Brazil, 99% <strong>of</strong> the cases are concentrated in the Amazônia<br />

region where the socioeconomic and natural environment conditions favor<br />

the proliferation <strong>of</strong> the vector mosquitoes <strong>of</strong> malaria.<br />

Many malaria control schemes have been elaborated in several<br />

countries but success has been below <strong>of</strong> expectancy. For the control<br />

strategies to be more efficient, scientists have been working to create<br />

genetically modified mosquitoes in or<strong>de</strong>r to encapsulate the Plasmodium.<br />

The i<strong>de</strong>a is to couple these mosquitoes with wild mosquitoes generating<br />

<strong>de</strong>scending refractory to the disease, which would substitute over the long<br />

range.<br />

In or<strong>de</strong>r to set the gui<strong>de</strong>lines for a successful mosquitoes substitution,<br />

the mathematical mo<strong>de</strong>ls <strong>of</strong> population evolution play an important role<br />

supplying a close-to-reality analysis. Though the formulation <strong>of</strong> an optimal<br />

control problem for these mo<strong>de</strong>ls, it is possible to indicate a viable, effective<br />

and low budget manner <strong>of</strong> specie substitution implementation.<br />

The mathematical mo<strong>de</strong>l proposed in this work contemplates the<br />

interaction between wild and genetically modified mosquitoes, being the last<br />

one the controller <strong>of</strong> system. The seasonal variation <strong>of</strong> the mosquitoes<br />

populational <strong>de</strong>nsity, which is a characteristic <strong>of</strong> the Amazônia region, also<br />

is taking into account.<br />

The control function consi<strong>de</strong>red in this work has two parts: the first<br />

one - feedforward control - maintains the system controlled on <strong>de</strong>sired<br />

trajectory; the other - feedback control - stabilizes the system around the<br />

<strong>de</strong>sired trajectory.<br />

Finally, the numerical experiments we have done have shown<br />

concordance <strong>of</strong> the mo<strong>de</strong>l with collected data and the effectiveness <strong>of</strong> the<br />

controller.<br />

Keywords: optimal control, malaria, genetically modified mosquitoes,<br />

seasonality<br />

Referências<br />

[WYS 05] Wyse, A.P, Bevilacqua, L. e Rafikov, M. Population Dynamics <strong>of</strong> An.<br />

darlingi in the Presence <strong>of</strong> Genetically Modified Mosquitoes with Refractoriness to<br />

Malaria. Proc. Symp. Math. Comp. Biol. 2005<br />

[RAF 04] Rafikov, M., Balthazar, J. M. Síntese do Controle ótimo Linear Feedback<br />

para Sistemas que Exibem Caos. Anais do 3° Congresso Temático <strong>de</strong> Dinâmica e<br />

Controle da SBMAC. Available at CD-Room. 2004<br />

[FNS 02] Programa Nacional <strong>de</strong> Prevenção e Controle da Malária, Brasília:<br />

Ministério da Saú<strong>de</strong>. Fundação Nacional da Saú<strong>de</strong> – FUNASA, 2002.<br />

[CAT 00] Catteruccia, F. et all, Stable germline transformation <strong>of</strong> the malaria<br />

mosquito Anopheles stephensi, Nature, 405 (2000) 959-962.<br />

[OGA 95] Ogata, K., Engenharia do Controle Mo<strong>de</strong>rno. Addison Wesley, 1995.

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