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Impact of - IDL-BNC @ IDRC - International Development Research ...

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glutathione reductase). The importance <strong>of</strong> protcases to hydrolyse ingested<br />

proteins in the presence <strong>of</strong> protein-digestion reducers must also be studied<br />

further.<br />

The role <strong>of</strong> botanical substances in plant-insect interactions must be investigated<br />

with emphasis on the basic mechanisms that underlie the insects'<br />

response to and avoidance <strong>of</strong> xenobiotics. Such studies will contribute to our<br />

understanding <strong>of</strong> the mechanisms involved in the development <strong>of</strong> insect<br />

resistance to chemicals and will facilitate biotechnological developments and<br />

improve pest-management strategies.<br />

The search for new, naturally occurring insecticides and synergists represents<br />

a challenge to pest-management specialists and toxicologists. The need to<br />

control an increasing number <strong>of</strong> resistant species requires the identification <strong>of</strong><br />

compounds with novel modes <strong>of</strong> action. No significant improvement in vector<br />

control can be envisaged without a drastic change in the nature <strong>of</strong> the biochemical<br />

tools available. They must have long-term economic benefits and be<br />

environmentally acceptable.<br />

Arnason, J.T.; Isman, M.B.; Philogène, B.J.R.; Waddell, T.G. 198Th. Mode <strong>of</strong> action<br />

<strong>of</strong> the sesquiterpene lactone tenulin from Helenium amarum against herbivorous<br />

insects. Journal <strong>of</strong> Natural Products, 50, 690-695.<br />

Arnason, J.T.; Philogene, B.J.R.; Morand, P.; Scaiano, J.C.; Werstiuk, N.; Lam, J.<br />

1987a. Thiophene and acetylenes: phototoxic agents to herbivorous and bloodfeeding<br />

insects. In Hcitz, JR.; Downum, K.R., ed., Light-activated pesticides.<br />

American Chemical Society, Washington, DC, USA. Symposium, 339,255-264.<br />

Arnason, J.T.; Towers, G.H.N.; Philogene, B.J.R.; Lambert, J.D.H. 1983. The role <strong>of</strong><br />

natural photosensitizers in plant resistance to insects. In Hedin, P., ed., Plant<br />

resistance to insects. American Chemical Society, Washington, DC, USA.<br />

Symposium, 208, 139-151.<br />

Bernard, C.B.; Arnason, J.T.; Philogène, B.J.R.; Lam, J.; Waddell, T. 1988. Effects <strong>of</strong><br />

lignans and other representative secondary metabolites <strong>of</strong> the Asteraceae on<br />

the MFO activity <strong>of</strong> the European corn borer, Ostrinia nubilalis Hubner (Lepidoptera:<br />

Pyralidae). Phytochemistry, 28, 1373-1378.<br />

Braunholtz, J.T. 1977. Pesticide development and the chemical manufacture. In<br />

Proceedings <strong>of</strong> the 15th international congress <strong>of</strong> entomologists. Entomological<br />

Society <strong>of</strong> America, College Park, MD, USA. Pp. 747-755.<br />

Brindley, W.A.; Scum, A.A. 1984. Synergism and antagonism in the analysis <strong>of</strong><br />

insecticide resistance. Environmental Entomology, 13, 348-353.<br />

Champagne, D.E.; Arnason, J.T.; Philogène, B.J.R.; Morand, P.; Lam, J. 1986. Lightmediated<br />

allelochemical effects <strong>of</strong> naturally occurring polyacetylenes and thiophenes<br />

from Asteraceae on herbivorous insects. Journal <strong>of</strong> Chemical Ecology,<br />

12, 835-858.<br />

289

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