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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 1183/MUM/2004 A
(22) Date of filing of Application: 04/11/2004 (43) Publication Date: 09/06/2006
(54) Title of the invention: A PROCESS FOR PREPARING TOLFENAMIC ACID
(51) International classification : A61K 7/00
(31) Priority Document No : NIL
(32) Priority Date : NIL
(33) Name of priority country : NIL
(86) International Application No : NIL
and Filing Date : NIL
(87) International Publication No : NIL
(61) Patent of addition to :
Application No
NIL
(62)
Filed on : N.A.
Divisional to Application No : NIL
Filed on : N.A.
(71) Name of Applicant:
ELDER PHARMACEUTICALS LTD.
Address of the Applicant:
ELDER HOUSE, PLOT NO.C/9,
DALIA INDL.ESTATE,
OFF.NEWLINKROAD, ANDHERI
(W), MUMBAI-400 058,INDIA.
(72) Name of the Inventor:
1. DR.R.R.SAKHARDANDE
2. MR.J.SAXENA
3. MR.N.K.KHATRI
4. MR.P.N.FIRKE
5. MR.R.V.PANCHAL
Filed U/S 5(2) before The Patents
(Amendment) Act, 2005: NO
(57) Abstract: A process for the preparation of pure tolfenamic acid comprising the following steps
a) reacting O-chlorobenzoic acid with potassium hydroxide to produce salt of potassium,
b) treating salt obtained at step (a) with calcium carbonate and with copper powder was reacted with 3chloro-2-
methyl aniline at a temperature range from 100 to 200C to afford a crude tolfenamic acid
c) purification of crude tolfenamic acid obtained at step (b) using a solvent sequentially to get pure
tolfenamic acid.
Drawing Sheets: NIL
Total Pages: 14.
Fig. Nil
The Patent Office Journal 09/06/2006 10872