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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 00248/KOLNP/2005 A
(22) Date of filing of Application: 23/02/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: USE OF DIGOXIN IMMUNE FAB FOR THE REGULATION OF SODIUM/POTASSIUM ATPASE
ACTIVITY IN PREECLAMPTIC AND ECLAMPTIC PATIENTS
(51) International classification : A61K
A61P 9/12
39/395,
(31) Priority Document No : 10/202,957
10/292,338
(32) Priority Date : 25/07/2002
12/11/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/023235
Filing Date
: & 24/07/2003
(87) International Publication No : WO 04/011028
(61) Patent of addition to Application No : NA
Filed on : NA
(62) Divisional to Application No : NA
Filed on : NA
(57) Abstract:
A method of regulating a preeclamptic/eclamptic patient's
sodium/potassium ATPase activity includes the administration of
digoxin immune Fab (ovine). Digoxin immune Fab (ovine) binds with
the endogenous digitalis-like factor to prevent it from interfering with
the functioning of the sodium/potassium ATPase, thereby allowing
the patient's intracellular sodium and calcium to return to a more
normal level. A method of controlling preeclampsia is also disclosed
that includes the steps of providing a supply of digoxin immune Fab
(ovine), calculating an appropriate dosage of the digoxin immune Fab
(ovine) based on a patient's weight and using an assumed endogenous
digitalis-like factor level, administering the appropriate dosage as an
intravenous bolus, and repeating the administration of the appropriate
dosage on a fixed schedule.
(FIG). 1
(71) Name of Applicant:
ADAIR, CHARLES, DAVID.,
Address of the Applicant:
22 MOUNTAIN ORCHARD PATH,
SIGNAL MOUNTAIN, TENNESSEE
37377 USA.
(72) Name of the Inventor:
ADAIR, CHARELS, DAVID
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
The Patent Office Journal 09/06/2006 10983