official journal of the patent office - Controller General of Patents ...

(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 01189/KOLNP/2005 A
(22) Date of filing of Application: 21/06/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE
INHIBITORES AND THEIR USE IN THE TREATMENT OF CANCER
(51) International classification : C07D 401/12,
407/14, 403/12,
407/12, 239/48,
417/12, 403/04,
403/14, 401/14,
A61K 31/506,
A61P 35/00
(31) Priority Document No : 60/428,473
60/438,568
60/523,081
(32) Priority Date : 21/11/2002
07/012003
19/11/2003
(33) Name of priority country : US
(86) International Application No and : PCT/US03/037294
Filing Date
: & 21/11/2003
(87) International Publication No : WO 04/048365
(61) Patent of addition to Application No : NA
Filed on : NA
(62) Divisional to Application No : NA
Filed on : NA
(57) Abstract:
Compounds having formula I are provided where the variables have
the values described herein. (I). Pharmaceutical formulations include
the compounds or pharmaceutically acceptable salts thereof and a
pharmaceutically acceptable carrier and combinations with other
agents. A method of treating a patient comprises administering a
pharmaceutical formulation according to the invention to a patient in
need thereof.
(FIG). Nil
(71) Name of Applicant:
CHIRON CORPORATION.,
Address of the Applicant:
4-38 MINATO-MACHI, 1-CHOME, NANIWA-KU,
OSAKA-SHI, OSAKA 556-0017, JAPAN.4560
HORTON STREET, EMERYVILLE, CA 94608-
2916, USA.
(72) Name of the Inventor:
1) NUSS, JOHN, M.
2) PECCHI, SABINA
3) RENHOWE, PAUL, A
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
The Patent Office Journal 09/06/2006 11080