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PATENT APPLICATION PUBLICATION
INDIA
Date of filing of Application: 03/07/2001
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(43)
(54) Title of the Invention: “A PHARMACEUTICAL COMPOSITION ”
(51) International Classification : A 61 P 31/18
A 61 K 31/495
(31) Priority Document No. : 60/107,116
60/115,653
(32) Priority Date : 5/11/1998
13/01/1999
(33) Name of priority country USA
(86) International application No. : PCT/US99/26157
Filing Date : 5 Nov, 1999
(87) International Publication No. : WO 00/26225
(61) Patent of Addition to
Application No.
:
N.A.
(62) Divisional to Application No. : NIL
Filed On : N.A.
Total No. of pages : 44+06=50
Application No.: IN/PCT/2001/00576/DEL
Publication Date:09/06/2006
(71) Name of Applicant :
CENTRE NATIONAL DE LA RECHERCHE
SCIENTIFIQUE.
THE UAB RESEARCH FOUNDATION EMORY
UNIVERSITY
Address of the Applicant: 3 rue Mechel-Ange,
F-75794 Paris Cedex 16, France,
1825 University Boulevard, Room 113, MJH,
Birmingham, AL 35294-2010, United States
of America
1380 S. Oxford Road, Atlanta, GA 30322,
United States of America.
(72) Name of the Inventor:
Gosselin, Gilles,
Imbach, Jean-louis,
Sommadossi, Jean-Pierre and
Schinazi, Raymond, F.
(57) Abstract: Compounds and pharmaceutical compositions active against hepatitis B virus are provided,
as is a method for the treatment of hepatitis B virus infection in humans and other host animals is provided
comprising administering an effective amount of a beta -L-(2' or 3'- azido)-2',3'-dideoxy-5-fluorocytosine of
formula (I) wherein R is H, acyl, monophosphate, diphosphate, or triphosphate, or a stabilized phosphate
derivative (to form a stabilized nucleotide prodrug), and R' is H, acyl, or alkyl.
The Patent Office Journal 09/06/2006 11099
A