official journal of the patent office - Controller General of Patents ...

(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 1226/MUM/2004 A
(22) Date of filing of Application: 10/112004 (43) Publication Date: 09/06/2006
(54) Title of the invention: FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF TUMOR
NECROSIS FACTOR-ALPHA
(51) International classification : C07D 327/02,
A61K 31/39,
C07D 411/04
(31) Priority Document No : NIL
(32) Priority Date : NIL
(33) Name of priority country : NIL
(86) International Application No : NIL
and Filing Date : NIL
(87) International Publication No : NIL
(61) Patent of addition to :
Application No
NIL
(62)
Filed on : N.A.
Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract: Fused Tricyclic Compounds as
inhibitors of Tumor Necrosis Factor-alpha
Compounds of Formula 1:
Are disclosed, wherein V is CH2, CHCH3 or C(CH3)2
or NH; W is S(O)m; m is the integer 0,1 or 2; in one
embodiment U is O; in another embodiment U is C9O),
CR13R14 or NR15; where R13 is H, alkyl, Cycloalkyl or
alkenyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl,
cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or
alkylaminocarbonyl; R1,R2,R3,R4,R5,R6,R7 and R8 are as
defined herein. These compounds are inhibitors of
tumor necrosis factor-alpha (TNF-���������������������
medicaments for the treatment and prevention of
disorders caused by increased TNF-����������������
particular inflammations.
Drawing Sheets: NIL
Total Pages: 90.
(71) Name of Applicant:
NICHOLAS PIRAMAL INDIA
LIMITED
Address of the Applicant:
NICHOLAS PIRAMAL TOWER,
PENINSULA CORPORATE PARK,
GANPATRAO KADAM MARG,
LOWER PAREL, MUMBAI-400 013,
MAHARASHTRA, INDIA.
(72) Name of the Inventor:
1. LAL BANSI
2. SHARMA SOMESH
3. GHOSH USHA
4. BAL-TEMBE SWATI
5. MORE TULSIDAS SITARAM
6. GAGARE PRAVIN
7. JADHAV SUNIL
8. PATIL SHASHIKANT
9. KULKARNI-ALMEIDA ASHA
10. PARIKH SAPNA HASIT
11. PANICKER RADHA BHASKAR
12. DAMRE ANAGHA ABHIJIT
13. GUPTE RAVINDRA
DATTATRAYA
Filed U/S 5(2) before The Patents
(Amendment) Act, 2005: NO
Fig. Nil
The Patent Office Journal 09/06/2006 10899