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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 01041/KOLNP/2005 A
(22) Date of filing of Application: 01/06/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: AGENT FOR PREVENTING OR TREATING NEUROPATHY
(51) International classification : A61K 31/381,
31/4155, 31/4174,
31/4178, 31/4184,
31/427, 31/402,
31/4439, 31/5377,
C07D 417/10,
417/12, 403/10,
403/12, 417/04,
(31) Priority Document No
231/12, C07F 9/40
: 2002-320153
(32) Priority Date : 01/11/2002
(33) Name of priority country : JAPAN
(86) International Application No and : PCT/JP03/013901
Filing Date
: & 30/10/2003
(87) International Publication No : WO 04/039365
(61) Patent of addition to Application No : NA
Filed on : NA
(62) Divisional to Application No : NA
Filed on : NA
(71) Name of Applicant:
TAKEDA PHARMECEUTICAL COMPANY
LIMITED
Address of the Applicant:
1-1, DOSHOMACHI 4-CHOME, CHUO-KU,
OSAKA-SHI, OSAKA 541-0045, JAPAN.
(72) Name of the Inventor:
1. MOMOSE, YU
2. SAKAI, NOZOMU
3. MAEKAWA, TSUYOSHI
4. HAZAMA, MASATOSHI
5. KAWAMURA, TORU
6. SERA, MISAYO
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
(57) Abstract:
The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent
comprises a compound represented by the formula:wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen
atoms, which may further have substituent(s);B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic
group;X is a divalent acyclic hydrocarbon group;Z is -O-, -S-, -NR2-, -CONR2- or -NR2CO- (R2 is a hydrogen atom or an optionally
substituted alkyl group);Y is a bond or a divalent acyclic hydrocarbon group;R1 is an optionally substituted cyclic group, an optionally
substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by
ring A is imidazole, then Z should not be -O-, or a salt thereof.
(FIG). nil
The Patent Office Journal 09/06/2006 11067