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PATENT APPLICATION PUBLICATION
INDIA
Date of filing of Application:01/01/2003
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(43)
Application No.: IN/PCT/2003/000008/DEL
Publication Date:09/06/2006
(54)Title of the Invention:. 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO
TREAT VCAM-1 MEDIATED DISORDERS
(51) International Classification : C07C49/796
(31) Priority Document No.
:
60/212,769
60/255,934
(32) Priority Date : 20/06/2000
15/12/2000
(33) Name of priority country USA
(86) International application No. : PCT/US01/19720
Filing Date : 20/06/2001
(87) International Publication No. : WO 01/98291
(61) Patent of Addition to
N.A.
Application No.
(62) Divisional to Application No. : N.A.
Filed On : N.A.
Total No. Pages : 220
:
(71)Name of Applicant:
ATHEROGENICS ,INC,
Address of the Applicant:
8995 Westside Parkway, Alpharetta, GA
30004, USA
(72)Name of the Inventor: :
MENG CHARLES Q
NI LIMING
SIKORSKI JAMES A
HOONG LEE K
Filed U/S 5(2) before The Patents
(Amendment) Ordinance, 2004 : YES
(57) Abstract: It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I)
inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of
inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis,
post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel
diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic
obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis,
atherosclerosis, coronary artery disease, angina and small artery disease.
The Patent Office Journal 09/06/2006 11141
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