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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 01058/KOLNP/2005 A
(22) Date of filing of Application: 03/06/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: DNA-BASED PLASMID FORMULATIONS AND VACCINES AND PROPHYLACTICS
CONTAINING THE SAME
(51) International classification : A61K
(31) Priority Document No : 10/288,251
(32) Priority Date : 04/11/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/034928
Filing Date
: 03/11/2003
(87) International Publication No : WO 04/041200 A2
(61) Patent of addition to Application No : NIL
Filed on : N.A.
(62) Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract:
(71) Name of Applicant:
PICOSCRIPT LTD LLP
Address of the Applicant:
8080N STADIUM DR HOUSTON TEXAS 77054
USA
(72) Name of the Inventor:
1. LASHER ALFRED W. III
2. KITTLE JOSEPH D JR.
3. WIDEN STEVEN G
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
The invention is a general method for improving the performance of the DNA-based vaccines. The method utilizes a complex DNAgenerated
profile of antigens to extend the effects of DNA-based vaccines and to broaden the immune response. This broadened immune
response in turn improves the protection of the recipient from divergent (but related) strains of a pathogen. In addition, it effectively
improves the efficacy of DNA-based vaccines used for treatment of viral diseases, including acquired immunity disorder (AIDS). One
embodiment, where the target viral pathogen is HIV (the causative agent for aids), the method identifies an orderly set of plasmids of
related sequences that may be used to prime a broad and strong immune response to HLA-restricted viral antigens. This mixture of
plasmids is thus capable of priming an appropriate immune response to reduce the viral burden in HIV infected patients or to protect
uninfected patients from HIV infection.
(FIG. - Nil)
The Patent Office Journal 09/06/2006 11073