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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 00229/KOLNP/2005 A
(22) Date of filing of Application: 21/02/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR
BETA PROTEINS
(51) International classification : A61K
38/07,38/08,38/10,3
8/18,C07K
5/00,7/00,14/495,15
/51
(31) Priority Document No : 60/402,733
(32) Priority Date : 13/08/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/025177
Filing Date
: 12/08/2003
(87) International Publication No : WO 04/014940 A3
(61) Patent of addition to Application No : NIL
Filed on : N.A.
(62) Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract:
(71) Name of Applicant:
WYETH
Address of the Applicant:
FIVE GIRALDA FARMS MADISON NJ
07940 USA
(72) Name of the Inventor:
1. NICHOLAS PILARIN E.L.
2. PEREZ RAMIREZ BERNARDO
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005:NO
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the
discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP2 has properties that enhance the solubility
of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide
comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the
solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-
2.
(FIG. Nil)
The Patent Office Journal 09/06/2006 10982