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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 00774/KOLNP/2005 A
(22) Date of filing of Application: 02/05/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: 4,6-DIAMINOSUBSTITUTED-2-[OXY OR AMIOXY]-[1,3,5] TRIAZINES AS PROTEIN
TYROSINE KINASE INHIBITORS
(51) International classification : C07D
417/12,A61K
31/53,A61P
43/00,C07D
401/12,417/14
(31) Priority Document No : 60/414,636
(32) Priority Date : 01/10/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/030491
Filing Date
: 29/09/2003
(87) International Publication No : WO 04/031184 A1
(61) Patent of addition to Application No : NIL
Filed on : N.A.
(62) Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract:
(71) Name of Applicant:
JOHNSON & JOHNSON PHARMACEUTICAL
RESEARCH & DEVELOPMENT INC
Address of the Applicant:
ONE JOHNSON & JOHNSON PLAZA NEW
BRUNSWICK NJ 08933 USA
(72) Name of the Inventor:
1. MARK R PALYER
2. NAND BAINDUR
3. BENJAMIN BRANDT
4. DAVOUD ASGARI
5. NARESH CHADHA
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
The invention is directed to compounds of Formulae (I, II, III) or (IV): wherein R, R1, R2, R3, A1 and A2 are set forth in the specification,
as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially
VEGFR-2 (KDR), c-fms, c-met and tie-2 kinases. The invention is also directed toward methods of preparation of the compounds of
Formulae (I, II, III) and (IV).
(FIG. -Nil)
The Patent Office Journal 09/06/2006 11017