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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 1184/MUM/2004 A
(22) Date of filing of Application: 04/11/2004 (43) Publication Date: 09/06/2006
(54) Title of the invention: A PROCESS FOR PREPARING DISOMIN
(51) International classification : A61K 37/00
(31) Priority Document No : NIL
(32) Priority Date : NIL
(33) Name of priority country : NIL
(86) International Application No : NIL
and Filing Date : NIL
(87) International Publication No : NIL
(61) Patent of addition to :
Application No
NIL
(62)
Filed on : N.A.
Divisional to Application No : NIL
Filed on : N.A.
(71) Name of Applicant:
ELDER PHARMACEUTICALS LTD.
Address of the Applicant:
ELDER HOUSE, PLOT NO.C/9,
DALIA INDL.ESTATE,
OFF.NEWLINKROAD, ANDHERI
(W), MUMBAI-400 058, INDIA.
(72) Name of the Inventor:
1. R.R.SAKHARDANDE
2. J.SAXENA
3. N.K.KHATRI
4. P.N.FIRKE
5. R.V.PANCHAL
Filed U/S 5(2) before The Patents
(Amendment) Act, 2005: NO
(57) Abstract: AN improved process for preparing pure diosmin, comprising the following steps,
a) dissolving hesperidine in a solvent followed by adding of sodium hydroxide under constant stirring,
b) adding iodine portion wise within one hour to the mixture obtained at step (a), kept mixture constant for a
period of 6-8 hrs at 80-90C
c) distillation of solvent followed by adding sodium thiosulphate, and water allowed to filter to get crude diosmin
followed by stirring with conc.Hcl allow to filter
d) conversion of crude diosmin into sodium salt by dissolution in NaoH, water and carbon-treated with followed
by filteration again treated with sulphuric acid until to achieve Ph-2,
e) filtering and washing the product obtained at step (d)
Drawing Sheets: NIL
Total Pages: 14.
Fig. Nil
The Patent Office Journal 09/06/2006 10873