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(12) (19) (22) PATENT APPLICATION PUBLICATION INDIA Date of filing of Application:26/12/2002 (21) (43) Application No.: IN/PCT/2002/01292/DEL Publication Date:09/06/2006 (54) Title of the Invention:. LIPOSOMAL BENZOQUINAZOLINE THYMIDYLATE SYNTHASE INHIBITOR FORMULATIONS. (51) International Classification : A61K 9/127 (31) Priority Document No. : 60/210,592 (32) Priority Date : 09/09/2000 (33) Name of priority country US (86) International application No. : PCT/US01/18224 Filing Date : 06/06/2001 (87) International Publication No. : WO 01/95884 (61) Patent of Addition to Application No. : N.A. (62) Divisional to Application No. : N.A Filed On : Total No. Pages : 84 (71)Name of Applicant: OSI PHARMACEUTICALS, INC Address of the Applicant: Suit 110, 58 South Service Road, Melville, New York 11747, USA. (72) Name of the Inventor: : CLAUDINE S. ASHVAR SU-MING CHIANG DAVID L. EMERSON NING HU GERARD M. JENSEN Filed U/S 5(2) before The Patents (Amendment) Ordinance, 2004 : NO (57) Abstract: Liposomal encapsulated benzoquinazoline thymidylate synthase inhibitor formulations are provided. The liposomes have improved pharmacokinetics and enhanced efficacy as anti-tumor agents compared to the free drug. The formulations include liposomes comprising at least one phosphatidylcholine, a cholesterol, and a benzoquinazoline thymidylate synthase inhibitor. The Patent Office Journal 09/06/2006 11123 A
(12) (19) (22) PATENT APPLICATION PUBLICATION INDIA Date of filing of Application:04/12/1998 (21) (43) Application No.: 3668/DEL/1998 Publication Date:09/06/2006 (54) Title of the Invention:. NEW DERIVATIVES OF ECHINOCANDIANE, THEIR PREPARATION PROCESS AND THEIR USE AS FUNGICIDES. (51) International Classification : C07K7/56, A61K 38/12 (31) Priority Document No. 97 15628 : 98 13361 (32) Priority Date : 10/12/1997 26/10/1998 (33) Name of priority country FRANCE (86) International application No. : NA Filing Date : NA (87) International Publication No. : NA (61) Patent of Addition to Application No. : N.A. (62) Divisional to Application No. : N.A Filed On : Total No. Pages : 84 (57) Abstract: A subject of the invention is the compounds of formula (I): (71)Name of Applicant: HOECHST MARION ROUSSEL Address of the Applicant: 1, Terrasse Bellini, F-92800 Puteaux, France (72) Name of the Inventor: : OLIVIER COURTIN PARTRICK FAUVEAU ASTRID MARKUS DOMINIQUE MELON-MANGUER JEAN-MARC MICHEL LAURENT SCHIO Filed U/S 5(2) before The Patents (Amendment) Ordinance, 2004 : YES -either R1 and R2 , H, OH, alkyl optionally substituted, -or NR1 form with the carbon carrying NR1R2 a double bond and R2 is Xra, X being O, NH OR N-alkyl and Ra being H, alkyl optionally substituted, -R=chain containing up to 30 carbon atoms, optionally containing one or more heteroatoms, one or more heterocycles, - T=H, CH3, CH2CONH2, CH2 C≡N, (CH2)2NH2, - Y=H, OH, Halogen, - W=H, OH - Z=H or CH3 - The products have anti-fungal proprieties The Patent Office Journal 09/06/2006 11124 A
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