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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 1225/MUM/2004 A
(22) Date of filing of Application: 10/11/2004 (43) Publication Date: 09/06/2006
(54) Title of the invention: TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON
EXCHANGE INHIBITORS
(51) International classification : C07D 327/08,
A61K 31/382,
A61P 25/28
(31) Priority Document No : NIL
(32) Priority Date : NIL
(33) Name of priority country : NIL
(86) International Application No : NIL
and Filing Date : NIL
(87) International Publication No : NIL
(61) Patent of addition to :
Application No
NIL
(62)
Filed on : N.A.
Divisional to Application No : NIL
Filed on : N.A.
(71) Name of Applicant:
NICHOLAS PIRAMAL INDIA
LIMITED
Address of the Applicant:
NICHOLAS PIRAMAL TOWER,
PENINSULA CORPORATE PARK,
GANPATRAO KADAM MARG,
LOWER PARAL, MUMBAI-400 013,
MAHARASHTRA, INDIA.
(72) Name of the Inventor:
1. LAL BANSI
2. BAL-TEMBE SWATI
3. GHOSH USHA
4. JAIN ARUN KUMAR
5. MORE TULSIDAS SITARAM
6. GHATE ANIL VASANTRAO
7. TRIVEDI JACQUELINE VINOD
8. PARIKH SAPNA HASIT
Filed U/S 5(2) before The Patents
(Amendment) Act, 2005: YES
(57) Abstract: Guanidine derivatives having a condensed tricyclic ring of formula 1:
are disclosed, wherein ring A and ring B are independently from each other a saturated or unsaturated 5-6or 7membered
ring, optionally having one or more heteroatoms selected from nitrogen, sulfur and oxygen; U is C9O),
CraRb, O,NR a or S(O)m; V is CR a R b or NR a ; W is S(O)m; wherein R a is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb
is H, alkyl, cycloalkyl, alkenyl or aralkyl; R b is H, alkyl, OH, OR a or OCOR a , and m is the integerO,1 OR 2;
R1,R2,R3,R4,R5,R6,R7 OR R8 is guanidine or guanidine carbonyl. These derivatives are sodium-proton exchange
inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with
ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and
diabetes.
Drawing Sheets: NIL
Total Pages: 289.
Fig. Nil
The Patent Office Journal 09/06/2006 10898