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(12)<br />

(19)<br />

(22)<br />

PATENT APPLICATION PUBLICATION<br />

INDIA<br />

Date <strong>of</strong> filing <strong>of</strong> Application:24/08/2001<br />

(21)<br />

(43)<br />

(54) Title <strong>of</strong> <strong>the</strong> Invention:. A PHARMACEUTICAL COMPOSITION<br />

(51) International Classification : A61k[ 31/18<br />

A61K 31/00<br />

(31) Priority Document No.<br />

60/106,664<br />

:<br />

(32) Priority Date : 02/11/1998<br />

(33) Name <strong>of</strong> priority country USA<br />

(86) International application No. : PCT/US99/25673<br />

Filing Date : 02/11/1997<br />

(87) International Publication No. : WO 00/25797<br />

(61) Patent <strong>of</strong> Addition to<br />

Application No.<br />

: N.A.<br />

(62) Divisional to Application No. : IN/PCT/2001/455/DEL<br />

Filed On : 01/06/2001<br />

Total No. <strong>of</strong> pages : 16<br />

Application No.: IN/PCT/2001/00758/DEL<br />

Publication Date:09/06/2006<br />

(71) Name <strong>of</strong> Applicant : TRIANGLE<br />

PHARMACEUTICALS , INC,<br />

Address <strong>of</strong> <strong>the</strong> Applicant:<br />

4 University Place, 4611 University Drive,<br />

Durham, NC 27707, USA<br />

(72) Name <strong>of</strong> <strong>the</strong> Inventor: :<br />

FURMAN PHILLIP A.<br />

PAINTER GEORGE R.<br />

BARRY DAVID<br />

ROUSSEAU FRANCK<br />

Filed U/S 5(2) before The <strong>Patents</strong><br />

(Amendment) Ordinance, 2004 : YES<br />

(57) Abstract: The present invention is directed to a method for treating hepatitis B virus infection in humans comprising<br />

administering a synergistically effective amount <strong>of</strong> agents having known anti-hepatitis B virus activity in combination or<br />

alternation. Specifically, <strong>the</strong> invention is directed to a method for treating hepatitis B virus infection comprising administering FTC<br />

in combination or alternation with penciclovir, famciclovir or Bis-POM-PMEA. Additionally, <strong>the</strong> invention is directed to a method<br />

for treating hepatitis B virus infection comprising administering L-FMAU in combination or alternation with DAPD, penciclovir or<br />

Bis-POM-PMEA. The invention is fur<strong>the</strong>r directed to a method for treating hepatitis B virus infection comprising administering<br />

DAPD in combination or alternation with Bis-POM-PMEA.<br />

The Patent Office Journal 09/06/2006 11119<br />

A

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