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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 01373/KOLNP/2005 A
(22) Date of filing of Application: 15/07/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF Y2
RECEPTOR –BINDING PEPTIDES AND METHODS FOR TREATING AND PREVENTING
OBESITY
(51) International classification : A61K 38/00
(31) Priority Document No : 10/322,266
(32) Priority Date : 17/12/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/040538
Filing Date
: 17/12/2003
(87) International Publication No : WO 04/056314 A3
(61) Patent of addition to Application No : NIL
Filed on : N.A.
(62) Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract:
(71) Name of Applicant:
NASTECH PHARMACEUTICAL COMPANY
INC
Address of the Applicant:
3450 MONTE VILLA PARKWAY BOTHELL
WA 98021 USA
(72) Name of the Inventor:
QUAY STEVEN C
BRANDT GORDON
KLEPPE MARY S
MACEVILLY CONOR J
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
Pharmaceutical compositions and methods are described comprising at least one peptide YY compound and one or more intranasal
delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in
mammalian subjects, including obesity. In one aspect, the intranasal delivery formulations and methods provide enhanced delivery of
peptide YY to the blood plasma or central nervous system (CNS) tissue or fluid, for example, by yielding a peak concentration (Cmax) of
the peptide YY in the blood plasma or CNS tissue or fluid of the subject that is 20% or greater compared to a peak concentration of the
peptide YY in the blood plasma or CNS tissue or fluid of the subject following administration to the subject of a same concentration or
dose of the peptide YY to the subject by subcutaneous injection.
(FIG. -Nil)
The Patent Office Journal 09/06/2006 11091