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(12)<br />

(19)<br />

(22)<br />

PATENT APPLICATION PUBLICATION<br />

INDIA<br />

Date <strong>of</strong> filing <strong>of</strong> Application:26/03/2003<br />

(21)<br />

(43)<br />

Application No.: 449/DELNP/2003<br />

Publication Date:09/06/2006<br />

(54)Title <strong>of</strong> <strong>the</strong> Invention:. TREATMENT OF URINARY DYSFUNCTION<br />

(51) International Classification : A61K 31/57<br />

(31) Priority Document No.<br />

:<br />

PQ 9687<br />

(32) Priority Date : 28/08/2000<br />

(33) Name <strong>of</strong> priority country AUSTRALIA<br />

(86) International application No. : PCT/AU01/01079<br />

Filing Date : 28/08/2001<br />

(87) International Publication No. : WO 02/17929<br />

(61) Patent <strong>of</strong> Addition to<br />

N.A.<br />

Application No.<br />

(62) Divisional to Application No. : N.A.<br />

Filed On : N.A.<br />

Total No. Pages : 12<br />

:<br />

(71)Name <strong>of</strong> Applicant: INTREAT PTY.<br />

LIMITED,<br />

Address <strong>of</strong> <strong>the</strong> Applicant:<br />

Level 10, 26 O’Connell Street, Sydney,<br />

New South Wales 2000, AUSTRALIA<br />

(72)Name <strong>of</strong> <strong>the</strong> Inventor: :<br />

BARDEN JULIAN ALEXANDER<br />

GIDLEY BAIRD ANGUS<br />

Filed U/S 5(2) before The <strong>Patents</strong><br />

(Amendment) Ordinance, 2004 : YES<br />

(57) Abstract: The invention provides a pharmaceutical composition for treatment or prevention <strong>of</strong> urinary dysfunction in a<br />

mammal. The composition includes a pharmaceutically effective amount <strong>of</strong> one or more substances capable <strong>of</strong> enabling <strong>the</strong><br />

bladder <strong>of</strong> <strong>the</strong> mammal to mimic conditions found in advanced pregnancy. Alternately, <strong>the</strong> pharmaceutical composition has a<br />

pharmaceutically effective amount <strong>of</strong> one or more substances adapted to regulate <strong>the</strong> expression <strong>of</strong> one or more ATPases that<br />

control <strong>the</strong> supply <strong>of</strong> ATP to P2X receptors in <strong>the</strong> bladder <strong>of</strong> <strong>the</strong> mammal. In one aspect, <strong>the</strong> pharmaceutical composition may<br />

downregulate expression <strong>of</strong> subtype receptors P2X1, P2X2, P2X3 and P2X5, possibly upregulating expression <strong>of</strong> subtype<br />

receptors P2X4 and P2X6.<br />

The Patent Office Journal 09/06/2006 11139<br />

A

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