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PATENT APPLICATION PUBLICATION
INDIA
Date of filing of Application:04/07/03
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Application No.: 01040/DELNP/2003
Publication Date:09/06/2006
(54)Title of the Invention:. DAPD COMBINATION THERAPY WITH INOSINE MONOPHOSPHATE
DEHYDROGENASE INHIBITOR
(51) International Classification : A61K31/365
(31) Priority Document No.
:
60/256,068
60/272,605
(32) Priority Date : 15/12/2000
01/03/2001
(33) Name of priority country USA
(86) International application No. : PCT/US01/48817
Filing Date : 12/12/2001
(87) International Publication No. : WO 02/068058
(61) Patent of Addition to
N.A.
Application No.
(62) Divisional to Application No. : N.A.
Filed On : N.A.
Total No. Pages : 48
:
(71)Name of Applicant: TRIANGLE
PHARMACEUTICALS, INC
Address of the Applicant:
4 University Place, 4611 University Drive ,
Durham, NC 27707-4674, USA.
(72) Name of the Inventor: :
FURMAN PHILLIP A
BORROTO –ESODA KATYNA.
Filed U/S 5(2) before The Patents
(Amendment) Ordinance, 2004 : YES
(57) Abstract: It has been unexpectedly found that a drug resistant strain of HIV exhibits the behavior of drug-naïve virus when
given the combination of a beta -D-1,3-dioxolanyl nucleoside and an IMPDH inhibitor. In one nonlimiting embodiment, the HIV
strain is resistant to a beta -D-1,3-dioxolanyl nucleoside.
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