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(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 00118/KOLNP/2005 A
(22) Date of filing of Application: 02/02/2005 (43) Publication Date: 09/06/2006
(54) Title of the invention: HCV FUSION PROTEINS WITH MODIFIED NS3 DOMAINS
(51) International classification : C12N
(31) Priority Document No : 60/393,694
(32) Priority Date : 02/07/2002
(33) Name of priority country : US
(86) International Application No and : PCT/US03/20996
Filing Date
: 02/07/2003
(87) International Publication No : WO 04/005473 A2
(61) Patent of addition to Application No : NIL
Filed on : N.A.
(62) Divisional to Application No : NIL
Filed on : N.A.
(57) Abstract:
(71) Name of Applicant:
CHIRON CORPORATION
Address of the Applicant:
4560 HORTON STREET, R440 EMERYVILLE
CA 94608 USA
(72) Name of the Inventor:
HOUGHTON MICHAEL
Filed U/S 5(2) before The Patents (Amendment)
Act, 2005: NO
The invention provides HCV fusion proteins that include a mutated NS3 protease domain, fused to at least one other HCV epitope
derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating a cellular immune response to
HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4 + and CD8 + T cells. The method can be used in model
systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
(FIG.nil)
The Patent Office Journal 09/06/2006 10976