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474 Integration of Behavior<br />

The patient was instructed to continue taking 500 mg of lithium carbonate<br />

twice daily and also to follow a low-salt diet. After some time in the clinic he was sent<br />

home again, remained well, and worked regularly on his new job.<br />

Three years later J. W. became listless and apathetic. He also complained of<br />

deafness and dryness of skin. Clinical examination revealed a hypothyroid condition,<br />

apparently produced by the lithium. This condition is called a side effect, which is an<br />

adverse and secondary outcome of treatment. When it was corrected by administration<br />

of thyroxin, the patient's health again returned to normal.<br />

During this period, the effects of lithium were tested by removing the drug<br />

and substituting a salt pill with no medicinal properties. As predicted, the thyroid problem<br />

disappeared and the periodic psychosis returned. Hence the patient was discharged<br />

from the hospital with prescriptions for lithium and also thyroxin, and he went home<br />

to normal health. Except for one minor disruption, when his dosage was incorrect, this<br />

satisfactory condition has continued.<br />

This history of J. W. emphasizes two points. First, a man who was essentially<br />

unemployable for 18 years and "impossible" at home worked regularly for four years<br />

and led a normal life under lithium treatment. Drug treatments, as his case shows, can<br />

be extremely helpful. Second, arriving at a proper prescription for any individual can<br />

be a complex, time-consuming task, often based on trial and error. The outcome can<br />

be influenced by diet, health, and constitutional factors; it can include unwanted side<br />

effects; and it can vary decidedly with the dosage (Musa, 1981). .<br />

Types of Therapeutic Drugs The chief drugs used with psychosis are known as<br />

antipsychotic drugs. One of these is lithium, used with J. W., and it can be especially<br />

effective in depression and manic-depressive disorders. But as the case of J. W. shows,<br />

drug treatment must be carefully monitored (Jefferson & Greist, 1981).<br />

Other antipsychotic drugs include Thorazine and Stelazine, recognized as effective<br />

in reducing hallucinations and delusions, evidently by blocking the activity of<br />

certain neurotransmitters that play a role in brain arousal. Like lithium, they diminish<br />

agitation to a point at which troubled patients can function in daily life and benefit<br />

from other treatments, such as occupational therapy, recreational activity, and psychotherapy.<br />

Also called major tranquilizers, these drugs are administered in cases of<br />

incomplete recovery from LSD ingestion.<br />

The minor tranquilizers, or antianxiety drugs, are used in less severe instances.<br />

They induce relaxation and serenity, and in this category Valium is probably most<br />

widely known today (Figure 17.15).<br />

There are also antidepressant drugs or mood-elevating drugs, such as Elavil<br />

and Tofranil. They stimulate the individual to increased activity and more interest in<br />

the world, but some require 10 to 21 days before they have an effect.<br />

Figure 17.15<br />

Psychiatric Drugs. The use of these<br />

drugs has increased precipitously in<br />

recent generations.<br />

Type of Drug<br />

Antipsychotic<br />

Antianxiety<br />

Antidepressant<br />

Generic Names<br />

Chlorpromazine<br />

Trifluoperazine<br />

Meprobamate<br />

Chlordiazepoxide<br />

Imipramine<br />

Amitriptyline<br />

Indications for Use<br />

Psychotic or other<br />

severe<br />

symptoms<br />

Mild<br />

maladjustment,<br />

anxiety<br />

Depression,<br />

agitation, and<br />

insomnia<br />

Possible Side Effects<br />

Dizziness, sleepiness, dry<br />

mouth, blurred vision,<br />

jaundice, liver damage<br />

Initial dizziness, possible<br />

addiction<br />

Anxiety, trembling, sleep<br />

problems, overt<br />

psychosis

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