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Concerns remain regarding the incidence of minor bleeding, consequent delayed wound healingand subsequent risk of infection. The aim of this observational study was to assess the incidenceof post-operative complications in patients receiving either rivaroxaban or enoxaparinthromboprophylaxis following elective hip and knee arthroplasty.Methods258 patients undergoing elective total hip or knee arthroplasty within one NHS Trust wereincluded. 202 subjects (mean age 70.7 years ± 10.0, 43% male) received a daily dose of 10mgof oral rivaroxaban and 56 (mean age 70.9 years ± 9.8, 39% male) had a daily subcutaneousinjection of 40 mg of enoxaparin as thromboprophylaxis. Endpoints included VTE (deep veinthrombosis and pulmonary embolism), haemorrhagic wound complications, hospital readmission,requirement for blood transfusion, minor and major bleeding and death.ResultsThere were no significant differences in the incidence of deep vein thrombosis, requirement forblood transfusion and readmission rate between rivaroxaban and enoxaparin-treated patients.However, the incidence of minor bleeding (2.0% versus 0%) and haemorrhagic woundcomplications (4.9% versus 1.8%) were non-significantly higher in the rivaroxaban-treatedgroup. There were no cases of pulmonary embolism, major bleeding or death in either group.ConclusionOur experience with rivaroxaban in elective hip and knee arthroplasty showed no significantdifference in the incidence of VTE or major bleeding. There was, however, a tendency togreater risk of minor bleeding and consequent delayed wound healing affecting both morbidityand delaying discharge. These may predispose patients to a higher risk of wound infection, andthus these issues require further large scale evaluation.Rivaroxaban Group n=202 Enoxaparin Group n=56DVT/PE 2 (1.0%) 1 (1.8%)Blood Transfusion (≥ 2 units) 13 (6.4%) 4 (7.1%)Wound complications 10 (4.9%) 1 (1.8%)Minor bleeding 4 (2.0%) 0Major bleeding 0 0Readmission 2 (1.0%) 1(1.8%)Death 0 0Friday, October 8, 2010, 16:30-17:20Session A16: Computer Navigation in THAAcetabular Component Placement in THR: A New CT-Image-BasedDedicate Software*Attilio Speranza - Sapienza University of Rome/Sant' Andrea Hospital - Rome, Italyfile:///E|/ISTA2010-Abstracts.htm[12/7/2011 3:15:47 PM]