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International scientific literature is full of articles that explain the characteristics and the use ofstem cells much more than their clinical effects and results.Friedlander (1) studied 122 patients with tibia pseudoartrosis who underwent to implant of rh-OP1/collagen type 1, showing both clinical and radiographic efficacy.Capanna (2) with his experience, shows that for the reparation of big bone loss and forpseudoartrosis treatment, association of bank bone innest and stem cells can be a goodresolution: he treated 27 patients, with neoplastic, post traumatic pathologies, aseptic necrosis ofthe hip, and he realized that the time of recovery was halved (3 months in front of 6 m.).Hernigou (4) studied 116 patients with osteonecrosis of the hip and who were treated withautologous bone marrow implantation: higher the number of innested cells higher the qualityand the quantity of the osteogenesis.During the 2008 and 2009 we have applied stem cells and growth factors to 36 patients. All thecases have been controlled using clinical and radiographical parameters. Clinical evaluationconsidered subjective index as pain and objective index as functional limitation.For radiographic evaluation we have done standardx-ray in two positions in the immediate postoperative period and after 1,3,6, and 12 month.Our results are: in recent fracture there has been observed an halved time of consolidation (60days in tibia and humerus fractures in front of the “classical”150 days ); in hypertrophicpseuroartrosis the healing was after 30-90 days. In recent fractures the application of combinedstem cells and growth factors has the aim to transform the “adult fracture” in “child fracture”:reparative process is faster and full of material because the number of stem cells present in thered bone marrow is higher in children. When the childhood is finished the red bone marrowbecome fat and it looses its capacity both hematopoietic and osteogenesis. Another fact is thatstem cells will diminish with the growth.Our casuistry has to be improved but in order to our experience we can affirm that this newbiological technique can be a good promise for the future: the high percentage of good results,the halved rehabilitation time and the possibility to ménage the bone loss can authorized us tobe positive to continue in this way.Poster: 85Use of Total Femur Prosthesis in Bone Tumor Treatment: The RizzoliInstitute Experience*Pietro Ruggieri - University of Bologna, Istituto Rizzoli - Bologna, ItalyElisa Pala - University of Bologna, Istituto Rizzoli - Bologna, ItalyMario Mercuri - University of Bologna - Bologna, Italy*Email: pietro.ruggieri@ior.itObjectives: aim of this study was to review a series of total femur prosthetic reconstructions forfile:///E|/ISTA2010-Abstracts.htm[12/7/2011 3:15:47 PM]