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Convened under the auspicious of esteemed endorsers - ISTA

Convened under the auspicious of esteemed endorsers - ISTA

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hours after presentation.Discussion and ConclusionOur data suggests that <strong>the</strong>re is a role for early aggressive open debridement in acute infectionsafter THA with an excellent chance <strong>of</strong> eradicating infection.Thursday, October 7, 2010, 16:50-17:40Session B8: Management <strong>of</strong> Complications in TKATranexamic Acid in Total Knee Replacements: A Meta-Analysis*Mohamed Sukeik - University College London Hospital - London, United KingdomSattar Alshryda - The James Cook University Hospital - Middlesbrogh, United KingdomAnthony Nargol - University Hospital Of North Tees - Stockton on Tees, United KingdomJames Mason - School Of Health, Durham University - Stockton on Tees, United KingdomIntroduction*Email: msukeik@hotmail.comTotal knee replacements (TKR) are among <strong>the</strong> commonest operations performed in orthopaedicpractice. Literature review showed that 10-30% <strong>of</strong> patients who <strong>under</strong>went TKR needed 1-3units <strong>of</strong> blood.Tranexamic acid (TXA) has been popularised as an effective way to reduce blood loss andsubsequent blood transfusion.Our aim was to investigate <strong>the</strong> value <strong>of</strong> TXA in reducing blood loss and blood transfusion afterTKR and o<strong>the</strong>r clinical outcomes such as deep venous thrombosis (DVT), pulmonary embolism(PE), ischaemic heart diseases and mortality.Patients and MethodsA systematic review and meta-analysis <strong>of</strong> published randomised and quasi-randomised trialswhich used TXA to reduce blood loss in knee arthroplasty were conducted.Results18 clinical trials were considered suitable for detailed data extraction. There were no trialswhich utilised TXA in revision TKR.Blood loss: Fourteen studies (885 patients) were eligible for this outcome. Using TXAsignificantly reduced postoperative blood loss by an average <strong>of</strong> 203.64.65 ml (P-value

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