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Poster: 38Intraarticular Injection of Tranexamic Acid Decreases Leg Swelling AfterTotal Knee Arthroplasty via Blood Loss Reduction*Kazunari Ishida - Hyogo Rehabilitation Centre Center Hospital - Kobe, JapanAtsushi Kitagawa - Hyogo Rehabilitation Center Hospital - Kobe, JapanSeiji Kubo - Kobe University - Kobe, JapanTomoyuki Matsumoto - Kobe University Graduate School of Medicine - Kobe, JapanMasahiro Kurosaka - Kobe University Graduate School of Medicine - Kobe, JapanRyosuke Kuroda - Department of Orthopaedic Surgery, Kobe University Graduate School ofMedicine - Kobe, Japan*Email: wavedreamer17@yahoo.co.jpPurpose: Tranexamic acid (TXA) is an inhibitor of fibrinolysis, and known toinhibit blood loss after total knee arthroplasty (TKA). In this study, weperformed randomized controlled trial to examine whether intraarticularinjection of TXA decreases leg swelling by reducing the blood loss after TKA.Materials and Methods: We performed one-hundred TKA with the patients of OA(men; 12 women; 88). At the closure, total of 2000 mg/20 mL TXA was injectedinto the knee joint through closed suction drain (TXA group). For the controlgroup, same volume of physiological saline was injected (control group). Theclosed drain was gradually opened post 30 minutes after injection.Preoperative conditions of these patients were examined and post operativehaemoglobin (Hb) level, blood loss through drain, D-dimer, and needs fortransfusion were compared with these two groups. Furthermore, circumferentialmeasurements of the leg (thigh, suprapatellar portion, and calf girth) weremeasured at pre, and post operation to investigate whether TXA influences theleg swelling post operation.Results: Postoperative decrease in Hb level was significantly down-regulatedin TXA group. Blood loss through drain were suppressed by 6 hours postoperation in TXA group, however the total blood loss through drain was thesame among these groups. Furthermore, supra-patellar girth at 1 week and calf girth at 2weeks post operation were significantly thinner in TXA group than in controlgroup.Conclusions: The results in this study indicated TXA decreases leg swelling via reducingblood loss. TXA has possibility to decrease patients’ discomfort via leg swelling reduction.Poster: 39Reconstruction of the Acetabulum With Extensive Bone Defect*Masaji Ishii - Saiseikai Yamagata Saisei Hospital - Yamagata, Japan*Email: ishii@ameria.orgReconstruction of the acetabulum with extensive bone defect is troublesome. Kerboull orKerboull type reinforcement acetabular device with allo bones grafting has been applied since1996. Clinical results of the reconstructive procedure were evaluated.file:///E|/ISTA2010-Abstracts.htm[12/7/2011 3:15:47 PM]