Cambridge International A Level Biology Revision Guide

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Cambridge International AS Level Biology Recommended resources Chapter 5 Further reading Alberts, B. et al. (2013) Essential Cell Biology, 4th edn. Garland Science. ■■ ■■ Chapter 5: ‘DNA and Chromosomes’ including ‘Chromosome coiling’, an animation showing how nucleosomes are formed as DNA is packaged into chromatin. Chapter 18: ‘The Cell Division Cycle’ including ‘Plant cell division’ and ‘Animal cell division’, which are narrated videos of actual plant and animal cells dividing. They are very clear. ‘Mitotic spindle’ Mitotic spindle is a striking picture of the mitotic spindle of a human cell taken using fluorescence microscopy. Available at: www.garlandscience.com/ECB4-students. Online and interactive resources www.hhmi.org/biointeractive BioInteractive is a free resource for teachers and students, including animations, short films and apps. (HHMI in the web address refers to the Howard Hughes Medical Institute.) www.hhmi.org/biointeractive/dna-packaging This page has an animation showing how DNA is packaged into chromosomes, including the formation of nucleosomes and chromatin. Mitosis is also shown. www.sciberbrain.org www.sciberbrain.org/advanced-level The Biochemical Society has set up a special website for education. There is an advanced-level animated presentation on stem cells, covering concepts such as potency. A lower-level presentation (standard level) is also available for a gentler introduction. http://cellpics.cimr.cam.ac.uk More information on stem cells and mitosis is available from this site. www.bbsrc.ac.uk/stemcellsresource Stem Cells: Science and Ethics (3rd edn) is a popular booklet on the science of stem cells and a consideration of the legal and ethical issues of research using stem cells. It contains classroom activities and discussion questions. Hard copies are available on request. www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC003374 Stem Cells: MRC Research for Lifelong Health is a booklet focusing on Medical Research Council (MRC)-funded research into stem cells, including their potential for repairing damaged body tissues. It also discusses ethical issues. Download from the MRC website either by using the direct link given, or by doing a search using the booklet’s title. A hard copy is also available the MRC. www.abpischools.org.uk/lib/liPoster/412/stem%20cell.pdf A clear and attractive poster on stem cell research, produced by the Association of British Pharmaceutical Societies (ABPI). www.johnkyrk.com John Kyrk’s website has an animation on mitosis. Cambridge International AS and A Level Biology © Cambridge University Press 2014
Cambridge International AS Level Biology Recommended resources Chapter 6 Further reading The three classic papers about the discovery of the molecular structure of DNA were published in Nature on 25 April 1953. The papers were reprinted on the 50th anniversary of their publication as the Double Helix 50th Anniversary Collection, Nature (2003) (www.nature.com/nature/dna50/ archive.html). Watson, J.D. and Crick, F.H.C. (1953) A structure for deoxyribose nucleic acid. Nature 171, 737–738. (Note that the authors’ names are not in alphabetical order: this was apparently decided by the toss of a coin.) Wilkins, M.H.F. et al. (1953) Molecular structure of deoxypentose nucleic acids. Nature 171, 738–740. Franklin, R.E. and Gosling, R.G. (1953) Molecular configuration in sodium thymonucleate. Nature 171, 740–741. Watson, J.D. and Crick, F.H.C. (1953) Genetical implications of the structure of deoxyribonucleic acid. Nature 171, 964–967. Watson and Crick published a second paper in 1953, elaborating their ideas. Watson, J.D. (1969) The Double Helix. Signet Books. James Watson has written several books about DNA. His light-hearted description of the discovery, The Double Helix, was first published in 1969 and has been republished many times since. He has also written A Passion for DNA and DNA: the Secret of Life. Maddox, B. (2003) Rosalind Franklin: The Dark Lady of DNA. HarperCollins. This is a good biography of Rosalind Franklin. (Maurice Wilkins referred to her as ‘the dark lady’.) Brenner, S. (2001) My Life in Science. BioMed Central. Sydney Brenner, with whom Crick worked on the triplet code, has written his autobiography. Alberts, B. et al. (2013) Essential Cell Biology, 4th edn. Garland Science. ■■ ■■ ■■ Chapter 5: ‘DNA and Chromosomes’ has DNA structure a narrated animation explaining the structure of DNA. Chapter 6: ‘DNA Replication, Repair and Recombination’, contains the animations ‘DNA polymerase’ and ‘DNA helicase’, are animations explaining how these molecules work. ‘Replication I’ I is a wonderful realistic animation of DNA replication in real time, giving a real insight into this almost miraculous process. The same animation can be seen and downloaded free of charge at www.hhmi.org/biointeractive/dna-replication-basic-detail or www.hhmi.org/ biointeractive/dna-replication-advanced-detail. The soundtrack is appropriately different in the basic and advanced versions and different again from the Alberts et al. (2013) versions. ‘Replication II’ is a more diagrammatic explanation of replication. Chapter 7: ‘From DNA to Protein: How Cells Read the Genome’ features ‘Transcription’ and ‘Translation I’, further superb real-time animations, showing the processes of transcription and translation. As with ‘Replication I’, the same animations can be seen and downloaded from the BioInteractive website, specifically www.hhmi.org/biointeractive/dna-transcription-basic-detail, www.hhmi.org/biointeractive/dna-transcription-advanced-detail, www.hhmi.org/biointeractive/ translation-basic-detail and www.hhmi.org/biointeractive/translation-advanced-detail with different soundtracks for all versions. Together with ‘Replication I’, these animations really bring Cambridge International AS and A Level Biology © Cambridge University Press 2014
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Chapter 3: Enzymes QUESTION 3.2 Why
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Chapter 3: Enzymes Enzyme inhibitor
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Chapter 10: Infectious diseases Ver
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Chapter 10: Infectious diseases 8 a
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Chapter 11: Immunity Smallpox was f
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Chapter 11: Immunity Summary ■■
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Chapter 11: Immunity 3 Which of the
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Chapter 11: Immunity 10 a Rearrange
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Chapter P1: Practical skills for AS
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Chapter 14: Homeostasis The hypotha
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Chapter 15: Coordination 329 Learni
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Chapter 16: Inherited change Katydi
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Chapter 17: Selection and evolution
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Chapter P2: Planning, analysis and
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Appendix 2: DNA and RNA triplet cod
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Glossary artery a blood vessel that
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Glossary creatinine a nitrogenous e
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Glossary haemoglobin the red pigmen
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Glossary negative feedback a proces
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Glossary reaction centre a molecule
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Glossary transfer RNA (tRNA) a fold
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Chapter 1: Cell structure Index C3
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Index gluconeogenesis, 317 glucose,
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Index pacemaker, 177 palisade mesop
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Index tar, 190, 191, 193 taste buds
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Acknowledgements Meiosis” in Tuat
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Cambridge International A Level Biology Revision Guide

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