24/06/2005 - Controller General of Patents, Designs, and Trade Marks

(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21)
(22) Date of filing of Application: 18/06/2003 (43)
(54) Title of the invention:
Application No: 611/MUMNP/2003 A
Publication Date: 24/06/2005
NOVEL PROCESS FOR THE SYNTHESIS OF 5-[4-FLUOROPHENYL]-1-[2-
((2R, 4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL]-ETHYL]-2-
ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID
PHENYLAMIDE
(51) International Classification : C 07 D 405/06 (71)
(31) Priority Document No. : 60/260,505
(32) Priority Date : 09/01/2001
(33) Name of priority country : U.S.A.
(86) International Application
No.
: PCT/IB01/02729
Filing Date : 27/12/2001
(87) International Publication
No.
: WO 02/055519 A2
(61) Patent of addition to
Application No.
: NIL
Filed on : N.A.
(62)
(57) Abstract:
Divisional to Application
No.
: NIL
Filed on : N.A.
(72)
Name of the Applicant:
WARNER-LAMBERT COMPANY LLC
Address of the Applicant:
201 TABOR ROAD, MORRIS PLAINS,
NEW JERSEY 07950,
UNITED STATES OF AMERICA.
Name of the Inventors:
1. DONALD EUGENE BUTLER
2. RANDALL LEE DEJONG
3. JADE DOUGLAS NELSON
4. MICHAEL GERARD PAMMENT
5. TIMOTHY LEE STUK
Filed U/S 5(2) before the
Patents (Amendment)
Ordinance, 2004: NO
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxotetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic
acid phenylamide by a
novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the
desired product, as well as other valuable intermediates used in the process.
(FIG.: NIL)
Total Pages: 68.
The Patent Office Journal 24.06.2005 17796