24/06/2005 - Controller General of Patents, Designs, and Trade Marks

(12) PATENT APPLICATION PUBLICATION
(19) INDIA (21) Application No.: 00151/MUMNP/2004 A
(22) Date of filing of Application: 27/02/2004 (43) Publication Date: 24/06/2005
(54) Title of the invention: : NOVEL PIPERIDIN-2,6-DIONE BISULPHATE SALTS AND THEIR
USE FOR THE TREATMENT OF STRESS-RELATED AFFECTIVE
DISORDERS
(51) International classification : A61K 31/45
(31) Priority Document No : 0120821.4
(32) Priority Date : 28/08/2001
(33) Name of priority country : UNITED
KINGDOM
(86) International Application
No and Filing Date:
(87) International Publication
No
(61) Patent of addition to
Application No
: PCT/GB2002/00386
9
22/08/2002
: WO 03/020275 A1
:
NIL
Filed on : N.A.
(62) Divisional to Application
No
: NIL
Filed on : N.A.
(71) Name of Applicant:
PRESTWICK PHARMACEUTICALS,
INC.
Address of the Applicant:
1825 K STREET N.W., SUITE 1475,
WASHINGTON DC 20006, USA.
(72) Name of the Inventor:
GITTOS MAURICE WARD
Filed U/S 5(2) before The
Patents (Amendment)
Ordinance, 2004: NO
(57) Abstract: Novel bisulphate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and
pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes in the rat which limited to
marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of
stress-related affective disorders such as anxiety, depression, migraine and sleep apnoea. The preferred bisulphate salts are
3(3,5-dimethoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione bisulphate and, especially, 3(3methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione
bisulphate.
(FIG.- NIL.)
Total Pages: 29.
The Patent Office Journal 24.06.2005 17913