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Phonation quality analysis to evaluate neurological diseases Gómez, Pedro; Rodellar, Victoria; Nieto, Víctor; Mazaira, Luis M.; Muñoz, Cristina; Fernández, Mario; Toribio, Elena Universidad Politécnica de Madrid; Hospital del Henares The monitoring of neurological diseases is of most importance in a world where population aging will demand important resources for health care. Classically Voice Quality Analysis has been focused in detecting and grading the organic pathology in voice. Nevertheless altered phonation due to neurological reasons may be a most valuable report of the progress of neural diseases resulting in voice tremor [1]. These would include some kinds of spasmodic dysphonia, stammering and Parkinson Disease (PD). The possibility of early detection in the first stages of PD may grant a better preventive treatment reducing the progress of the illness [2]. The deepest causes of the pathologies studied are to be found in the neurological paths involved in voice production from the neuromotor linguistic cortex [3], the subthalamic region [4] and through the laryngeal nerve and their associated pathways [5] to the muscles activating the thyro-arytenoid structure, responsible of vocal fold stretching, adduction and abduction. Any alteration in the functionality of these structures will result in temporary or permanent distortions of the biomechanical parameters (viscoelasticity) of the vocal folds. Correlates of these alterations will be found in the pitch, and very long term jitter and shimmer, as the periodicity of these alterations may be of hundreds of milliseconds [6]. The aim of this paper is to give some preliminary results in detecting and grading the neurological disease using biomechanical correlates obtained from the inverse filtering of voice [7]. A database of voice recordings from neurological disease-affected patients is being recorded in Hospital del Henares of Madrid. For the preliminary and explorative character of the present study some specific cases are selected, these being mild and strong spasmodic voice samples from male patients, and spasm-free voice from normophonic subjects to serve as a control. The methodology has been tested in monitoring pre-post treatment of organic pathology, and due to its ubiquitous character can be applied as well to neurological diseases. [1] Pantazis, Y., et al., "A novel method for the extraction of tremor", Proc. of MAVEBA07, Florence University Press 2007, pp. 107-110. [2] Das, R. "A comparison of multiple classification methods for diagnosis of Parkinson disease", Expert Systems with Applications, 2010, 1568-1572. [3] Rauschecker, J. P., Scott, S. K., "Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing", Nature Neuroscience, 2009, pp. 718-724. [4] Törnqvist, A. L., et al., "Effects of different electrical parameter settings on the intelligibility of speech in patients with Parkinson's Disease treated with subthalamic deep brain stimulation", Mov. Disord., 2004, pp. 416-423. [5] Luschei, E. S., et al., "Discharge characteristics of laryngeal single motor units during phonation in young and older adults and in persons with Parkinson disease", J. Neurophysiol., 1999, pp. 2131-2139. 51
[6] *Tsanas, A., et al., "Accurate telemonitoring of Parkinson's disease progression by non-invasive speech tests", IEEE Trans. Biomed. Eng., 2009, pp. 884-893. [7] *Gómez, P., et al., "Glottal Source Biometrical Signature for Voice Pathology Detection", Speech Communication, 2009, pp. 759-781. 52
Page 4: ÍNDICE: POR SECCIONES CONFERENCIAS
Page 7 and 8: Aspectos fonéticos de estabilidad
Page 9 and 10: Más allá del 'efecto CSI': Avance
Page 11 and 12: Hualde, J. I., M. Nadeu y M. Simone
Page 13 and 14: PONENCIAS 10
Page 15 and 16: Présentation en DVD du Proyect AMP
Page 17 and 18: Aproximación a la prosodia de las
Page 19 and 20: Fonética o fonología: ¿por dónd
Page 21 and 22: En conclusión, como puede verse po
Page 23 and 24: Mecanismos de la competencia fonét
Page 25 and 26: MESAS REDONDAS 22
Page 27 and 28: La sonorización de las oclusivas s
Page 29 and 30: S1. Fonética Articulatoria 26
Page 31 and 32: Observaciones sobre la articulació
Page 33 and 34: Jackson, M. (1988): “Analysis of
Page 35 and 36: Las consonantes líquidas implosiva
Page 37 and 38: S2. Fonética Acústica 34
Page 39 and 40: Caracterización acústica de vocal
Page 41 and 42: MATEO, J. (2001): La investigación
Page 43 and 44: Descripción fonético-acústica de
Page 45 and 46: Caracterización acústica de las a
Page 47 and 48: Estudio perceptivo de las marcas pr
Page 49 and 50: Integración audiovisual durante la
Page 51 and 52: Póster - Labguistic: a web platfor
Page 53: Análisis acústico de la prominenc
Page 57 and 58: S5. Fonética Forense 54
Page 59 and 60: S6. Fonética y Fonología 56
Page 61 and 62: La entonación prelingüística del
Page 63 and 64: Fortition and lenition patterns. De
Page 65 and 66: S7. Fonética Aplicada a las Tecnol
Page 67 and 68: conclusion we will describe how the
Page 69 and 70: According to these promising result
Page 71 and 72: Adquisición y aprendizaje del comp
Page 73 and 74: La estructuración acentual: estudi
Page 75 and 76: Adquisición de los fonemas españo
Page 77 and 78: Enunciados interrogativos totales:
Page 79 and 80: El Enfoque Oral en la adquisición
Page 81 and 82: Póster - Interferencias fónicas d
Page 83 and 84: Producción de las vocales labializ
Page 85 and 86: S9. Español como Lengua Extranjera
Page 87 and 88: La práctica de la fonética a trav
Page 89 and 90: Consideraciones metodológicas para
Page 91 and 92: Algunas creencias de profesores de
Page 93 and 94: La prosodia de las preguntas polare
Page 95 and 96: Análisis contrastivo de la entonac
Page 97 and 98: El acento léxico en contexto: dato
Page 99 and 100: Percepción del alineamiento tonal
Page 101 and 102: Giannini 2000, Pettorino 2003), dur
Page 103 and 104: Transferencia prosódica del italia
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Clases de interrogativas absolutas
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Se ha utilizado el software R de pr
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Henriksen, Nicholas Carl. 2010. Que
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Cortesía y descortesía en expresi
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Rasgos melódicos de la intensifica
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Recursos fónicos en críticas, rep
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Las llamadas "construcciones incomp
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Entonación y actitudes lingüísti
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Análisis multisistémico de la par
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S13. Proyectos 120
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El habla en Extremadura: cuestiones
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Variação prosódica em interrogat
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AMPER-Cuba: La entonación de oraci
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Análise Entonacional de Frases Dec
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Entonación de las interrogativas t
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Declarativas e interrogativas en zo
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Datos para la descripción de la pr
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PENNY, R. 2004: «Contínuum dialec
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O Arquipélago da Madeira no Projec
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Rasgos prosódicos del español de
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Sosa, J. M. (1999). La entonación
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español peninsular estándar segú
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La investigación prosódica del es
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La percepción de la incredulidad:
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Hacia un Enfoque Holístico en la E
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El entrenamiento musical y otros fa
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ÍNDICE: POR SECCIÓN CONFERENCIAS
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Enfoque perceptivo y contrastivo de
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Consideraciones metodológicas para
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Entonación de las interrogativas t
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Bernal Linnersand, María - S12: Pr
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Dordron de Pinho, José Ricardo - S
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González Rodríguez, Ruth - S11: P
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Mazaira, Luis M. - S4: Fonética Cl
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Quezada, Camilo - S4: Fonética Cl
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Schwab, Sandra - S3: Fonética Perc
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ÍNDICE: CORREOS ELECTRÓNICOS Agui
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Gabriel, Christoph - Gamal, Dalia -
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Pazos, José Manuel - Pérez, Carol
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