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6 - Varici reticolari e telangectasie<br />

factor β up regulates elastic gene expression <strong>in</strong> human sk<strong>in</strong> fibroblasts: evidence for<br />

post transcriptional modulation. Lab Invest, 1992; 66: 580-587.<br />

8. Majesky MW, L<strong>in</strong>der V, Twardzik DR, Schwartz SM, Reidy MS. Production of<br />

transform<strong>in</strong>g growth factor β dur<strong>in</strong>g repair of arterial <strong>in</strong>jury. J Cl<strong>in</strong> Invest, 1991; 88:<br />

904-910.<br />

9. Border WA, Noble NA. Transform<strong>in</strong>g growth factor β <strong>in</strong> tissue fibrosis. N Engl J Med,<br />

1994; 197: 287-1292.<br />

10. Raghow R. Role of transform<strong>in</strong>g growth factor β <strong>in</strong> repair and fibrosis. Chest, 1991; 99:<br />

615-655.<br />

114<br />

6.3 - Trattamento Endoperivenoso con Laser 808 nm: primi pisultati a distanza<br />

6.3 - Trattamento Endoperivenoso<br />

con Laser 808 nm: primi pisultati a distanza<br />

ABSTRACT:<br />

Crippa A.<br />

OBJECTIVES: In comb<strong>in</strong>ation with usual transdermal therapy at 532 nm<br />

treatment, we have evaluated also 808 nm wave-length laser <strong>in</strong> <strong>in</strong>tra-extra lum<strong>in</strong>al<br />

procedure for the treatment of teleangectasias. Endolaser<strong>in</strong>g with 100 or<br />

200 µm micro optical fibres can cause photothermocoagulation of the vessel<br />

wall thanks to the direct <strong>in</strong>tra-extra venous contact.<br />

In fact, 808 nm be<strong>in</strong>g scarcely absorbed by both water and fat tissue, does not<br />

harm surround<strong>in</strong>g perivenous tissues dur<strong>in</strong>g photocoagulation. When the fir<strong>in</strong>g<br />

becomes from the extravasal side, the first target is the adventitial vasa venarum.<br />

MATERIALS AND METHODS: S<strong>in</strong>ce march 2008, 300 patients (270<br />

female, 30 male) present<strong>in</strong>g tortuous teleangectasias are treated with <strong>in</strong>tra-extra<br />

lum<strong>in</strong>al 808 nm diode Laser (Eufoton, Trieste, Italy). After topical anaesthesia<br />

(EMLA Cream or cryogenic local therapy), a special micro fiber of 100 or<br />

200µm <strong>in</strong> teleangectasias are <strong>in</strong>serted <strong>in</strong>tra - extra near the ve<strong>in</strong>s wall, us<strong>in</strong>g at<br />

the same time a comb<strong>in</strong>ed sk<strong>in</strong> cool<strong>in</strong>g system dur<strong>in</strong>g and after treatment. We<br />

differentiate 2 types of teleangectasias treatments.<br />

a. Telangectasias sized from 0,5 mm to 1 mm (blue, violet).<br />

We used a special titanium <strong>in</strong>troducer for 25 G needle to <strong>in</strong>troduce<br />

easily the fiber <strong>in</strong>to the needle. Sk<strong>in</strong> temperature must be controlled<br />

by palpation. The fiber is pushed up where the reflux orig<strong>in</strong>ates and<br />

115

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