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Food additives data book - wordpres

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Nutritive Additives 612<br />

NAME: Biotin<br />

CATEGORY: Nutritive additive<br />

FOOD USE: Dietary supplements/ Dietetic foods/ Infant formulae/ Meal replacements/ Substitute foods<br />

SYNONYMS: D-Biotin/ Bios II B/ Coenzyme R/ Egg white injury factor/ Vitamin H/ CAS 58-85-5/<br />

EINECS 200-399-3<br />

FORMULA: C10 H16N2 O3S<br />

MOLECULAR MASS: 244.31<br />

ALTERNATIVE FORMS: There are eight stereoisomers, with naturally occurring D-biotin exhibiting the highest biological<br />

activity, while DL-biotin only contains half that activity and L-biotin is biologically inactive<br />

PROPERTIES: Heat stable<br />

APPEARANCE: D-biotin is commercially available in white crystalline and powder forms<br />

MELTING RANGE IN °C: 232–233<br />

SOLUBILITY % AT VARIOUS TEMPERATURE/pH COMBINATIONS:<br />

in water: @ 25°C ~22 mg/100 ml<br />

in ethanol solution: @ 95% ~80 mg/100 ml<br />

FUNCTION IN FOODS: Enrichment, fortification, or restoration<br />

TECHNOLOGY OF USE IN FOODS: Serial dilution required; dilution can be made using dicalcium phosphate; pH is not critical for use;<br />

biotin becomes inactive when combined with avidin in raw egg-white<br />

ANTAGONISTS: Subject to oxidative deterioration when exposed to oxidising agents such as potassium permanganate or<br />

hydrogen peroxide; UV light<br />

FOOD SAFETY ISSUES: No toxic symptoms as a result of heavy biotin dosage have been reported in humans

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