Food additives data book - wordpres

SYNERGISTS: With isomalt, it masks the metallic aftertaste of saccharin or aspartame.
Synergistic with cyclamates, aspartame, sucrose, isomalt, stevioside, NHDC (Neohesperidin);
synergism has been reported with fructose, sorbitol, xylitol and sucralose
FOOD SAFETY ISSUES: May have anticariogenic properties. Is not metabolised by the body, so has no calorific value; is
excreted unchanged.
Some research has shown an increase in bladder tumours in rats fed a saccharin :cyclamate blend;
this was later confirmed to be caused by the saccharin component of the blend. Effect was determined
to be species-specific as studies of those who consume large doses, such as diabetics, revealed no link
between saccharin and bladder tumours in humans.
LEGISLATION:
USA:
FDA withdrew GRAS in 1972 and attempted to ban its use in 1977.
All products packaged in the US must bear a statement warning that saccharin has been shown to cause cancer in laboratory animals.
Only all-purpose non-nutritive sweetener approved for use in the US.
ADI level as of 1990 for use in soft-drinks: 12 mg/fluid ounce
CFR 21
PART 100 – General
Subpart G ® Specific Administrative Rulings and Decisions
100.130 Combinations of nutritive and non-nutritive sweeteners in “diet beverages”.
As a result of the removal of cyclamic acid and its salts from the list of substances generally recognised as safe (part 182 of this chapter) by an order
published in the FEDERAL REGISTER of October 21, 1969 (34 FR 17063), the Commissioner of Food and Drugs has received inquiries as to the
proper composition and labelling, from the standpoint of application of the Federal Food, Drug, and Cosmetic Act, of so-called “diet beverages” that will
be made from mixtures of nutritive sweeteners and saccharin or its salts. The Commissioner concludes that:
(2) The label must bear a statement of the caloric content per fluid ounce, the carbohydrate content per fluid ounce, a statement of the percentage of
saccharin or saccharin salt used, and the statement “Contains •• mg saccharin (or saccharin salt, as the case may be) per ounce, a non-nutritive artificial
sweetener.”
CFR 21
PART 100 – General
Subpart A – General Provisions
Saccharin 961